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MCAK activity at microtubule tips regulates spindle microtubule length to promote robust kinetochore attachment

Mitotic centromere-associated kinesin (MCAK) is a microtubule-depolymerizing kinesin-13 member that can track with polymerizing microtubule tips (hereafter referred to as tip tracking) during both interphase and mitosis. MCAK tracks with microtubule tips by binding to end-binding proteins (EBs) thro...

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Detalles Bibliográficos
Autores principales: Domnitz, Sarah B., Wagenbach, Michael, Decarreau, Justin, Wordeman, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328376/
https://www.ncbi.nlm.nih.gov/pubmed/22492725
http://dx.doi.org/10.1083/jcb.201108147

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