Cargando…

53BP1 deficiency combined with telomere dysfunction activates ATR-dependent DNA damage response

TRF1 protects mammalian telomeres from fusion and fragility. Depletion of TRF1 leads to telomere fusions as well as accumulation of γ-H2AX foci and activation of both the ataxia telangiectasia mutated (ATM)– and the ataxia telangiectasia and Rad3 related (ATR)–mediated deoxyribonucleic acid (DNA) da...

Descripción completa

Detalles Bibliográficos
Autores principales:	Martínez, Paula, Flores, Juana M., Blasco, Maria A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328378/ https://www.ncbi.nlm.nih.gov/pubmed/22508511 http://dx.doi.org/10.1083/jcb.201110124

Ejemplares similares

Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-Ras(G12V)-induced lung cancer by induction of telomeric DNA damage
por: García-Beccaria, María, et al.
Publicado: (2015)

In vivo role of checkpoint kinase 2 in signaling telomere dysfunction
por: García-Beccaria, María, et al.
Publicado: (2014)

ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase
por: McNees, Carolyn J., et al.
Publicado: (2010)

Cooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA
por: Choi, Jun-Hyuk, et al.
Publicado: (2009)

53BP1 Mediates the Fusion of Mammalian Telomeres Rendered Dysfunctional by DNA-PKcs Loss or Inhibition
por: Rybanska-Spaeder, Ivana, et al.
Publicado: (2014)

Consequences of telomere dysfunction in fibroblasts, club and basal cells for lung fibrosis development
por: Piñeiro-Hermida, Sergio, et al.
Publicado: (2022)

Regulation of ATR-dependent DNA damage response by nitric oxide
por: Yeo, Chay Teng, et al.
Publicado: (2021)

DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs
por: Rossiello, Francesca, et al.
Publicado: (2017)

Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres
por: Povedano, Juan Manuel, et al.
Publicado: (2018)

Corrigendum: DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs
por: Rossiello, Francesca, et al.
Publicado: (2017)

Essential role for the TRF2 telomere protein in adult skin homeostasis
por: Martínez, Paula, et al.
Publicado: (2014)

Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage
por: Gibbs-Seymour, Ian, et al.
Publicado: (2015)

A p53-Dependent Response Limits Epidermal Stem Cell Functionality and Organismal Size in Mice with Short Telomeres
por: Flores, Ignacio, et al.
Publicado: (2009)

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway
por: Rizzo, Angela, et al.
Publicado: (2009)

DNA Damage Activates the SAC in an ATM/ATR-Dependent Manner, Independently of the Kinetochore
por: Kim, Eun Mi, et al.
Publicado: (2008)

The Impact of p53 Dysfunction in ATR Inhibitor Cytotoxicity and Chemo- and Radiosensitisation
por: Middleton, Fiona K., et al.
Publicado: (2018)

ATR contributes to telomere maintenance in human cells
por: Pennarun, Gaëlle, et al.
Publicado: (2010)

The Shieldin complex mediates 53BP1-dependent DNA repair
por: Noordermeer, Sylvie M., et al.
Publicado: (2018)

A role of the 53BP1 protein in genome protection: structural and functional characteristics of 53BP1-dependent DNA repair
por: Bártová, Eva, et al.
Publicado: (2019)

Short and dysfunctional telomeres protect from allergen‐induced airway inflammation
por: Piñeiro‐Hermida, Sergio, et al.
Publicado: (2021)

Combined ATR and DNA-PK Inhibition Radiosensitizes Tumor Cells Independently of Their p53 Status
por: Hafsi, Hind, et al.
Publicado: (2018)

ATR and p-ATR are emerging prognostic biomarkers and DNA damage response targets in ovarian cancer
por: Feng, Wenlong, et al.
Publicado: (2020)

Telomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells
por: Nakamura, Asako J., et al.
Publicado: (2009)

Telomere-driven diseases and telomere-targeting therapies
por: Martínez, Paula, et al.
Publicado: (2017)

Recruitment Kinetics of DNA Repair Proteins Mdc1 and Rad52 but Not 53BP1 Depend on Damage Complexity
por: Hable, Volker, et al.
Publicado: (2012)

Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response
por: Kao, Gary D., et al.
Publicado: (2003)

FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function
por: Tang, Mengfan, et al.
Publicado: (2020)

Telomerase deficiency and dysfunctional telomeres in the lung tumor microenvironment impair tumor progression in NSCLC mouse models and patient-derived xenografts
por: Piñeiro-Hermida, Sergio, et al.
Publicado: (2023)

A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenance
por: Martínez, Paula, et al.
Publicado: (2016)

Dysfunctional telomeres induce p53‐dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation
por: Wang, Yang, et al.
Publicado: (2016)

Tumor Suppressor P53 Binding Protein 1 (53bp1) Is Involved in DNA Damage–Signaling Pathways
por: Rappold, Irene, et al.
Publicado: (2001)

Lamin B1 sequesters 53BP1 to control its recruitment to DNA damage
por: Etourneaud, Laure, et al.
Publicado: (2021)

53BP1: Keeping It under Control, Even at a Distance from DNA Damage
por: Rass, Emilie, et al.
Publicado: (2022)

AKT-dependent signaling of extracellular cues through telomeres impact on tumorigenesis
por: Sánchez-Vázquez, Raúl, et al.
Publicado: (2021)

WWOX modulates the ATR-mediated DNA damage checkpoint response
por: Abu-Odeh, Mohammad, et al.
Publicado: (2015)

DNA damage causes rapid accumulation of phosphoinositides for ATR signaling
por: Wang, Yu-Hsiu, et al.
Publicado: (2017)

Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis
por: Minter-Dykhouse, Katherine, et al.
Publicado: (2008)

APE1 recruits ATRIP to ssDNA in an RPA-dependent and -independent manner to promote the ATR DNA damage response
por: Lin, Yunfeng, et al.
Publicado: (2023)

Fission Yeast Shelterin Regulates DNA Polymerases and Rad3(ATR) Kinase to Limit Telomere Extension
por: Chang, Ya-Ting, et al.
Publicado: (2013)

Modulation of ATR-mediated DNA damage checkpoint response by cryptochrome 1
por: Kang, Tae-Hong, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_3v6cd63alv2sh5b21ig98nvdp0