Human telomeres replicate using chromosome-specific, rather than universal, replication programs

Telomeric and adjacent subtelomeric heterochromatin pose significant challenges to the DNA replication machinery. Little is known about how replication progresses through these regions in human cells. Using single molecule analysis of replicated DNA (SMARD), we delineate the replication programs—i.e...

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Detalles Bibliográficos
Autores principales: Drosopoulos, William C., Kosiyatrakul, Settapong T., Yan, Zi, Calderano, Simone G., Schildkraut, Carl L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328383/
https://www.ncbi.nlm.nih.gov/pubmed/22508510
http://dx.doi.org/10.1083/jcb.201112083

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