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Munc13-4 reconstitutes calcium-dependent SNARE-mediated membrane fusion

Munc13-4 is a widely expressed member of the CAPS/Munc13 protein family proposed to function in priming secretory granules for exocytosis. Munc13-4 contains N- and C-terminal C2 domains (C2A and C2B) predicted to bind Ca(2+), but Ca(2+)-dependent regulation of Munc13-4 activity has not been describe...

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Detalles Bibliográficos
Autores principales:	Boswell, Kristin L., James, Declan J., Esquibel, Joseph M., Bruinsma, Stephen, Shirakawa, Ryutaro, Horiuchi, Hisanori, Martin, Thomas F.J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328385/ https://www.ncbi.nlm.nih.gov/pubmed/22508512 http://dx.doi.org/10.1083/jcb.201109132

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