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Molecular Requirements for Peroxisomal Targeting of Alanine-Glyoxylate Aminotransferase as an Essential Determinant in Primary Hyperoxaluria Type 1

Alanine-glyoxylate aminotransferase is a peroxisomal enzyme, of which various missense mutations lead to irreversible kidney damage via primary hyperoxaluria type 1, in part caused by improper peroxisomal targeting. To unravel the molecular mechanism of its recognition by the peroxisomal receptor Pe...

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Detalles Bibliográficos
Autores principales:	Fodor, Krisztián, Wolf, Janina, Erdmann, Ralf, Schliebs, Wolfgang, Wilmanns, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328432/ https://www.ncbi.nlm.nih.gov/pubmed/22529745 http://dx.doi.org/10.1371/journal.pbio.1001309

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