Iron Accumulation in Deep Cortical Layers Accounts for MRI Signal Abnormalities in ALS: Correlating 7 Tesla MRI and Pathology

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by cortical and spinal motor neuron dysfunction. Routine magnetic resonance imaging (MRI) studies have previously shown hypointense signal in the motor cortex on T(2)-weighted images in some ALS patients, h...

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Detalles Bibliográficos
Autores principales: Kwan, Justin Y., Jeong, Suh Young, Van Gelderen, Peter, Deng, Han-Xiang, Quezado, Martha M., Danielian, Laura E., Butman, John A., Chen, Lingye, Bayat, Elham, Russell, James, Siddique, Teepu, Duyn, Jeff H., Rouault, Tracey A., Floeter, Mary Kay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328441/
https://www.ncbi.nlm.nih.gov/pubmed/22529995
http://dx.doi.org/10.1371/journal.pone.0035241

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