The Q705K Polymorphism in NLRP3 Is a Gain-of-Function Alteration Leading to Excessive Interleukin-1β and IL-18 Production

BACKGROUND: The Q705K polymorphism in NLRP3 has been implicated in several chronic inflammatory diseases. In this study we determine the functional role of this commonly occurring polymorphism using an in-vitro system. PRINCIPAL FINDINGS: NLRP3-WT and NLRP3-Q705K were retrovirally transduced into th...

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Detalles Bibliográficos
Autores principales: Verma, Deepti, Särndahl, Eva, Andersson, Henrik, Eriksson, Per, Fredrikson, Mats, Jönsson, Jan-Ingvar, Lerm, Maria, Söderkvist, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328489/
https://www.ncbi.nlm.nih.gov/pubmed/22529966
http://dx.doi.org/10.1371/journal.pone.0034977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328489/
https://www.ncbi.nlm.nih.gov/pubmed/22529966
http://dx.doi.org/10.1371/journal.pone.0034977

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