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Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges

Bacterial flagellin is a dominant innate immune activator of the intestine. Therefore, we examined the role of the intracellular flagellin receptor, NLRC4, in protecting the gut and/or driving inflammation. In accord with NLRC4 acting via transcription-independent pathways, loss of NLRC4 did not red...

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Detalles Bibliográficos
Autores principales:	Carvalho, Frederic A., Nalbantoglu, Ilke, Aitken, Jesse D., Uchiyama, Robin, Su, Yueju, Doho, Gregory H., Vijay-Kumar, Matam, Gewirtz, Andrew T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328601/ https://www.ncbi.nlm.nih.gov/pubmed/22318495 http://dx.doi.org/10.1038/mi.2012.8

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