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Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis

For more than a decade, researchers have been trying to develop non-invasive imaging techniques for the in vivo measurement of viable pancreatic beta cells. However, in spite of intense research efforts, only one tracer for positron emission tomography (PET) imaging is currently under clinical evalu...

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Autores principales: Andralojc, K., Srinivas, M., Brom, M., Joosten, L., de Vries, I. J. M., Eizirik, D. L., Boerman, O. C., Meda, P., Gotthardt, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328679/
https://www.ncbi.nlm.nih.gov/pubmed/22358499
http://dx.doi.org/10.1007/s00125-012-2491-7
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author Andralojc, K.
Srinivas, M.
Brom, M.
Joosten, L.
de Vries, I. J. M.
Eizirik, D. L.
Boerman, O. C.
Meda, P.
Gotthardt, M.
author_facet Andralojc, K.
Srinivas, M.
Brom, M.
Joosten, L.
de Vries, I. J. M.
Eizirik, D. L.
Boerman, O. C.
Meda, P.
Gotthardt, M.
author_sort Andralojc, K.
collection PubMed
description For more than a decade, researchers have been trying to develop non-invasive imaging techniques for the in vivo measurement of viable pancreatic beta cells. However, in spite of intense research efforts, only one tracer for positron emission tomography (PET) imaging is currently under clinical evaluation. To many diabetologists it may remain unclear why the imaging world struggles to develop an effective method for non-invasive beta cell imaging (BCI), which could be useful for both research and clinical purposes. Here, we provide a concise overview of the obstacles and challenges encountered on the way to such BCI, in both native and transplanted islets. We discuss the major difficulties posed by the anatomical and cell biological features of pancreatic islets, as well as the chemical and physical limits of the main imaging modalities, with special focus on PET, SPECT and MRI. We conclude by indicating new avenues for future research in the field, based on several remarkable recent results.
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spelling pubmed-33286792012-05-14 Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis Andralojc, K. Srinivas, M. Brom, M. Joosten, L. de Vries, I. J. M. Eizirik, D. L. Boerman, O. C. Meda, P. Gotthardt, M. Diabetologia Review For more than a decade, researchers have been trying to develop non-invasive imaging techniques for the in vivo measurement of viable pancreatic beta cells. However, in spite of intense research efforts, only one tracer for positron emission tomography (PET) imaging is currently under clinical evaluation. To many diabetologists it may remain unclear why the imaging world struggles to develop an effective method for non-invasive beta cell imaging (BCI), which could be useful for both research and clinical purposes. Here, we provide a concise overview of the obstacles and challenges encountered on the way to such BCI, in both native and transplanted islets. We discuss the major difficulties posed by the anatomical and cell biological features of pancreatic islets, as well as the chemical and physical limits of the main imaging modalities, with special focus on PET, SPECT and MRI. We conclude by indicating new avenues for future research in the field, based on several remarkable recent results. Springer-Verlag 2012-02-23 2012 /pmc/articles/PMC3328679/ /pubmed/22358499 http://dx.doi.org/10.1007/s00125-012-2491-7 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Review
Andralojc, K.
Srinivas, M.
Brom, M.
Joosten, L.
de Vries, I. J. M.
Eizirik, D. L.
Boerman, O. C.
Meda, P.
Gotthardt, M.
Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis
title Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis
title_full Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis
title_fullStr Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis
title_full_unstemmed Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis
title_short Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis
title_sort obstacles on the way to the clinical visualisation of beta cells: looking for the aeneas of molecular imaging to navigate between scylla and charybdis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328679/
https://www.ncbi.nlm.nih.gov/pubmed/22358499
http://dx.doi.org/10.1007/s00125-012-2491-7
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