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Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis
For more than a decade, researchers have been trying to develop non-invasive imaging techniques for the in vivo measurement of viable pancreatic beta cells. However, in spite of intense research efforts, only one tracer for positron emission tomography (PET) imaging is currently under clinical evalu...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328679/ https://www.ncbi.nlm.nih.gov/pubmed/22358499 http://dx.doi.org/10.1007/s00125-012-2491-7 |
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author | Andralojc, K. Srinivas, M. Brom, M. Joosten, L. de Vries, I. J. M. Eizirik, D. L. Boerman, O. C. Meda, P. Gotthardt, M. |
author_facet | Andralojc, K. Srinivas, M. Brom, M. Joosten, L. de Vries, I. J. M. Eizirik, D. L. Boerman, O. C. Meda, P. Gotthardt, M. |
author_sort | Andralojc, K. |
collection | PubMed |
description | For more than a decade, researchers have been trying to develop non-invasive imaging techniques for the in vivo measurement of viable pancreatic beta cells. However, in spite of intense research efforts, only one tracer for positron emission tomography (PET) imaging is currently under clinical evaluation. To many diabetologists it may remain unclear why the imaging world struggles to develop an effective method for non-invasive beta cell imaging (BCI), which could be useful for both research and clinical purposes. Here, we provide a concise overview of the obstacles and challenges encountered on the way to such BCI, in both native and transplanted islets. We discuss the major difficulties posed by the anatomical and cell biological features of pancreatic islets, as well as the chemical and physical limits of the main imaging modalities, with special focus on PET, SPECT and MRI. We conclude by indicating new avenues for future research in the field, based on several remarkable recent results. |
format | Online Article Text |
id | pubmed-3328679 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-33286792012-05-14 Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis Andralojc, K. Srinivas, M. Brom, M. Joosten, L. de Vries, I. J. M. Eizirik, D. L. Boerman, O. C. Meda, P. Gotthardt, M. Diabetologia Review For more than a decade, researchers have been trying to develop non-invasive imaging techniques for the in vivo measurement of viable pancreatic beta cells. However, in spite of intense research efforts, only one tracer for positron emission tomography (PET) imaging is currently under clinical evaluation. To many diabetologists it may remain unclear why the imaging world struggles to develop an effective method for non-invasive beta cell imaging (BCI), which could be useful for both research and clinical purposes. Here, we provide a concise overview of the obstacles and challenges encountered on the way to such BCI, in both native and transplanted islets. We discuss the major difficulties posed by the anatomical and cell biological features of pancreatic islets, as well as the chemical and physical limits of the main imaging modalities, with special focus on PET, SPECT and MRI. We conclude by indicating new avenues for future research in the field, based on several remarkable recent results. Springer-Verlag 2012-02-23 2012 /pmc/articles/PMC3328679/ /pubmed/22358499 http://dx.doi.org/10.1007/s00125-012-2491-7 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Review Andralojc, K. Srinivas, M. Brom, M. Joosten, L. de Vries, I. J. M. Eizirik, D. L. Boerman, O. C. Meda, P. Gotthardt, M. Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis |
title | Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis |
title_full | Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis |
title_fullStr | Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis |
title_full_unstemmed | Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis |
title_short | Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis |
title_sort | obstacles on the way to the clinical visualisation of beta cells: looking for the aeneas of molecular imaging to navigate between scylla and charybdis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328679/ https://www.ncbi.nlm.nih.gov/pubmed/22358499 http://dx.doi.org/10.1007/s00125-012-2491-7 |
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