Temozolomide in aggressive pituitary adenomas and carcinomas

Temozolomide is an alkylating agent used in the treatment of gliomas and, more recently, aggressive pituitary adenomas and carcinomas. Temozolomide methylates DNA and, thereby, has antitumor effects. O(6)-methylguanine-DNA methyltransferase, a DNA repair enzyme, removes the alkylating adducts that a...

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Detalles Bibliográficos
Autores principales: Ortiz, Leon D., Syro, Luis V., Scheithauer, Bernd W., Rotondo, Fabio, Uribe, Humberto, Fadul, Camilo E., Horvath, Eva, Kovacs, Kalman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328813/
https://www.ncbi.nlm.nih.gov/pubmed/22584716
http://dx.doi.org/10.6061/clinics/2012(Sup01)20

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