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Releasing the Brake: Targeting Cbl-b to Enhance Lymphocyte Effector Functions

The E3 ubiquitin ligase Cbl-b is an established nonredundant negative regulator of T-cell activation. Cbl-b fine-tunes the activation threshold of T cells and uncouples T cells from their vital need of a costimulatory signal to mount a productive immune response. Accordingly, mice deficient in cblb...

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Detalles Bibliográficos
Autores principales:	Wallner, Stephanie, Gruber, Thomas, Baier, Gottfried, Wolf, Dominik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328896/ https://www.ncbi.nlm.nih.gov/pubmed/22550535 http://dx.doi.org/10.1155/2012/692639

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