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Efficacy and Safety of a Chinese Herbal Medicine Formula (RCM-104) in the Management of Simple Obesity: A Randomized, Placebo-Controlled Clinical Trial

Objective. This study was to evaluate the efficacy and safety of a Chinese herbal medicine formula (RCM-104) for the management of simple obesity. Method. Obese subjects aged between 18 and 60 years were selected for 12-week, double-blind, randomized, placebo-controlled trial. Subjects were randomly...

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Autores principales: Lenon, George Binh, Li, Kang Xiao, Chang, Yung-Hsien, Yang, Angela Weihong, Da Costa, Clifford, Li, Chun Guang, Cohen, Marc, Mann, Neil, Xue, Charlie C. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328918/
https://www.ncbi.nlm.nih.gov/pubmed/22550541
http://dx.doi.org/10.1155/2012/435702
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author Lenon, George Binh
Li, Kang Xiao
Chang, Yung-Hsien
Yang, Angela Weihong
Da Costa, Clifford
Li, Chun Guang
Cohen, Marc
Mann, Neil
Xue, Charlie C. L.
author_facet Lenon, George Binh
Li, Kang Xiao
Chang, Yung-Hsien
Yang, Angela Weihong
Da Costa, Clifford
Li, Chun Guang
Cohen, Marc
Mann, Neil
Xue, Charlie C. L.
author_sort Lenon, George Binh
collection PubMed
description Objective. This study was to evaluate the efficacy and safety of a Chinese herbal medicine formula (RCM-104) for the management of simple obesity. Method. Obese subjects aged between 18 and 60 years were selected for 12-week, double-blind, randomized, placebo-controlled trial. Subjects were randomly assigned to take 4 capsules of either the RCM-104 formula (n = 59) or placebo (n = 58), 3 times daily for 12 weeks. Measures of BW, BMI and WC, HC, WHR and BF composition were assessed at baseline and once every four weeks during the 12 week treatment period. Results. Of the 117 subjects randomised, 92 were included in the ITT analysis. The weight, BMI and BF in RCM-104 group were reduced by 1.5 kg, 0.6 kg/m(2) and 0.9% and those in the placebo group were increased by 0.5 kg, 0.2 kg/m(2) and 0.1% respectively. There were significant differences in BW and BMI (P < 0.05) between the two groups. Eleven items of the WLQOQ were significantly improved in the RCM-104 group while only 2 items were significantly improved in the placebo group. Adverse events were minor in both groups. Conclusion. RCM-104 treatment appears to be well tolerated and beneficial in reducing BW and BMI in obese subjects.
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spelling pubmed-33289182012-05-01 Efficacy and Safety of a Chinese Herbal Medicine Formula (RCM-104) in the Management of Simple Obesity: A Randomized, Placebo-Controlled Clinical Trial Lenon, George Binh Li, Kang Xiao Chang, Yung-Hsien Yang, Angela Weihong Da Costa, Clifford Li, Chun Guang Cohen, Marc Mann, Neil Xue, Charlie C. L. Evid Based Complement Alternat Med Research Article Objective. This study was to evaluate the efficacy and safety of a Chinese herbal medicine formula (RCM-104) for the management of simple obesity. Method. Obese subjects aged between 18 and 60 years were selected for 12-week, double-blind, randomized, placebo-controlled trial. Subjects were randomly assigned to take 4 capsules of either the RCM-104 formula (n = 59) or placebo (n = 58), 3 times daily for 12 weeks. Measures of BW, BMI and WC, HC, WHR and BF composition were assessed at baseline and once every four weeks during the 12 week treatment period. Results. Of the 117 subjects randomised, 92 were included in the ITT analysis. The weight, BMI and BF in RCM-104 group were reduced by 1.5 kg, 0.6 kg/m(2) and 0.9% and those in the placebo group were increased by 0.5 kg, 0.2 kg/m(2) and 0.1% respectively. There were significant differences in BW and BMI (P < 0.05) between the two groups. Eleven items of the WLQOQ were significantly improved in the RCM-104 group while only 2 items were significantly improved in the placebo group. Adverse events were minor in both groups. Conclusion. RCM-104 treatment appears to be well tolerated and beneficial in reducing BW and BMI in obese subjects. Hindawi Publishing Corporation 2012 2012-02-20 /pmc/articles/PMC3328918/ /pubmed/22550541 http://dx.doi.org/10.1155/2012/435702 Text en Copyright © 2012 George Binh Lenon et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lenon, George Binh
Li, Kang Xiao
Chang, Yung-Hsien
Yang, Angela Weihong
Da Costa, Clifford
Li, Chun Guang
Cohen, Marc
Mann, Neil
Xue, Charlie C. L.
Efficacy and Safety of a Chinese Herbal Medicine Formula (RCM-104) in the Management of Simple Obesity: A Randomized, Placebo-Controlled Clinical Trial
title Efficacy and Safety of a Chinese Herbal Medicine Formula (RCM-104) in the Management of Simple Obesity: A Randomized, Placebo-Controlled Clinical Trial
title_full Efficacy and Safety of a Chinese Herbal Medicine Formula (RCM-104) in the Management of Simple Obesity: A Randomized, Placebo-Controlled Clinical Trial
title_fullStr Efficacy and Safety of a Chinese Herbal Medicine Formula (RCM-104) in the Management of Simple Obesity: A Randomized, Placebo-Controlled Clinical Trial
title_full_unstemmed Efficacy and Safety of a Chinese Herbal Medicine Formula (RCM-104) in the Management of Simple Obesity: A Randomized, Placebo-Controlled Clinical Trial
title_short Efficacy and Safety of a Chinese Herbal Medicine Formula (RCM-104) in the Management of Simple Obesity: A Randomized, Placebo-Controlled Clinical Trial
title_sort efficacy and safety of a chinese herbal medicine formula (rcm-104) in the management of simple obesity: a randomized, placebo-controlled clinical trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328918/
https://www.ncbi.nlm.nih.gov/pubmed/22550541
http://dx.doi.org/10.1155/2012/435702
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