Suboptimal Immune Reconstitution in Vertically HIV Infected Children: A View on How HIV Replication and Timing of HAART Initiation Can Impact on T and B-cell Compartment

Today, HIV-infected children who have access to treatment face a chronic rather than a progressive and fatal disease. As a result, new challenges are emerging in the field. Recent lines of evidence outline several factors that can differently affect the ability of the immune system to fully reconsti...

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Detalles Bibliográficos
Autores principales: Cotugno, Nicola, Douagi, Iyadh, Rossi, Paolo, Palma, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328919/
https://www.ncbi.nlm.nih.gov/pubmed/22550537
http://dx.doi.org/10.1155/2012/805151
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author Cotugno, Nicola
Douagi, Iyadh
Rossi, Paolo
Palma, Paolo
author_facet Cotugno, Nicola
Douagi, Iyadh
Rossi, Paolo
Palma, Paolo
author_sort Cotugno, Nicola
collection PubMed
description Today, HIV-infected children who have access to treatment face a chronic rather than a progressive and fatal disease. As a result, new challenges are emerging in the field. Recent lines of evidence outline several factors that can differently affect the ability of the immune system to fully reconstitute and to mount specific immune responses in children receiving HAART. In this paper, we review the underlying mechanisms of immune reconstitution after HAART initiation among vertically HIV-infected children analyzing the possible causes of suboptimal responses.
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spelling pubmed-33289192012-05-01 Suboptimal Immune Reconstitution in Vertically HIV Infected Children: A View on How HIV Replication and Timing of HAART Initiation Can Impact on T and B-cell Compartment Cotugno, Nicola Douagi, Iyadh Rossi, Paolo Palma, Paolo Clin Dev Immunol Review Article Today, HIV-infected children who have access to treatment face a chronic rather than a progressive and fatal disease. As a result, new challenges are emerging in the field. Recent lines of evidence outline several factors that can differently affect the ability of the immune system to fully reconstitute and to mount specific immune responses in children receiving HAART. In this paper, we review the underlying mechanisms of immune reconstitution after HAART initiation among vertically HIV-infected children analyzing the possible causes of suboptimal responses. Hindawi Publishing Corporation 2012 2012-04-08 /pmc/articles/PMC3328919/ /pubmed/22550537 http://dx.doi.org/10.1155/2012/805151 Text en Copyright © 2012 Nicola Cotugno et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Cotugno, Nicola
Douagi, Iyadh
Rossi, Paolo
Palma, Paolo
Suboptimal Immune Reconstitution in Vertically HIV Infected Children: A View on How HIV Replication and Timing of HAART Initiation Can Impact on T and B-cell Compartment
title Suboptimal Immune Reconstitution in Vertically HIV Infected Children: A View on How HIV Replication and Timing of HAART Initiation Can Impact on T and B-cell Compartment
title_full Suboptimal Immune Reconstitution in Vertically HIV Infected Children: A View on How HIV Replication and Timing of HAART Initiation Can Impact on T and B-cell Compartment
title_fullStr Suboptimal Immune Reconstitution in Vertically HIV Infected Children: A View on How HIV Replication and Timing of HAART Initiation Can Impact on T and B-cell Compartment
title_full_unstemmed Suboptimal Immune Reconstitution in Vertically HIV Infected Children: A View on How HIV Replication and Timing of HAART Initiation Can Impact on T and B-cell Compartment
title_short Suboptimal Immune Reconstitution in Vertically HIV Infected Children: A View on How HIV Replication and Timing of HAART Initiation Can Impact on T and B-cell Compartment
title_sort suboptimal immune reconstitution in vertically hiv infected children: a view on how hiv replication and timing of haart initiation can impact on t and b-cell compartment
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328919/
https://www.ncbi.nlm.nih.gov/pubmed/22550537
http://dx.doi.org/10.1155/2012/805151
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