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The Prognostic Value of suPAR Compared to Other Inflammatory Markers in Patients with Severe Sepsis
It has been suggested that soluble urokinase plasminogen activator (suPAR) can be used as a marker of disease severity and risk of mortality in sepsis. The aim with the present study was to compare plasma levels of suPAR in patients with severe sepsis to control subjects and correlate it with the le...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329189/ https://www.ncbi.nlm.nih.gov/pubmed/22550400 http://dx.doi.org/10.4137/BMI.S9460 |
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author | Gustafsson, Anna Ljunggren, Lennart Bodelsson, Mikael Berkestedt, Ingrid |
author_facet | Gustafsson, Anna Ljunggren, Lennart Bodelsson, Mikael Berkestedt, Ingrid |
author_sort | Gustafsson, Anna |
collection | PubMed |
description | It has been suggested that soluble urokinase plasminogen activator (suPAR) can be used as a marker of disease severity and risk of mortality in sepsis. The aim with the present study was to compare plasma levels of suPAR in patients with severe sepsis to control subjects and correlate it with the level of inflammatory activation, severity and mortality. Samples were collected from 27 sepsis patients at the intensive care unit (ICU), Lund, Sweden; 90-day mortalities were registered. The suPAR level was significantly elevated in sepsis patients compared to controls, but not significantly higher in nonsurvivors than survivors. Plasma levels of suPAR did correlate weakly with the SOFA score and myeloperoxidase (MPO) but not with CRP, PCT, IL-6 or IL-10 in patients with severe sepsis. The weak correlation between suPAR and other inflammatory markers might suggest that suPAR reflects general activation of the immune system rather than exerting inflammatory actions. |
format | Online Article Text |
id | pubmed-3329189 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-33291892012-05-01 The Prognostic Value of suPAR Compared to Other Inflammatory Markers in Patients with Severe Sepsis Gustafsson, Anna Ljunggren, Lennart Bodelsson, Mikael Berkestedt, Ingrid Biomark Insights Original Research It has been suggested that soluble urokinase plasminogen activator (suPAR) can be used as a marker of disease severity and risk of mortality in sepsis. The aim with the present study was to compare plasma levels of suPAR in patients with severe sepsis to control subjects and correlate it with the level of inflammatory activation, severity and mortality. Samples were collected from 27 sepsis patients at the intensive care unit (ICU), Lund, Sweden; 90-day mortalities were registered. The suPAR level was significantly elevated in sepsis patients compared to controls, but not significantly higher in nonsurvivors than survivors. Plasma levels of suPAR did correlate weakly with the SOFA score and myeloperoxidase (MPO) but not with CRP, PCT, IL-6 or IL-10 in patients with severe sepsis. The weak correlation between suPAR and other inflammatory markers might suggest that suPAR reflects general activation of the immune system rather than exerting inflammatory actions. Libertas Academica 2012-04-10 /pmc/articles/PMC3329189/ /pubmed/22550400 http://dx.doi.org/10.4137/BMI.S9460 Text en © the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article. Unrestricted non-commercial use is permitted provided the original work is properly cited. |
spellingShingle | Original Research Gustafsson, Anna Ljunggren, Lennart Bodelsson, Mikael Berkestedt, Ingrid The Prognostic Value of suPAR Compared to Other Inflammatory Markers in Patients with Severe Sepsis |
title | The Prognostic Value of suPAR Compared to Other Inflammatory Markers in Patients with Severe Sepsis |
title_full | The Prognostic Value of suPAR Compared to Other Inflammatory Markers in Patients with Severe Sepsis |
title_fullStr | The Prognostic Value of suPAR Compared to Other Inflammatory Markers in Patients with Severe Sepsis |
title_full_unstemmed | The Prognostic Value of suPAR Compared to Other Inflammatory Markers in Patients with Severe Sepsis |
title_short | The Prognostic Value of suPAR Compared to Other Inflammatory Markers in Patients with Severe Sepsis |
title_sort | prognostic value of supar compared to other inflammatory markers in patients with severe sepsis |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329189/ https://www.ncbi.nlm.nih.gov/pubmed/22550400 http://dx.doi.org/10.4137/BMI.S9460 |
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