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Role of Direct Repeat and Stem-Loop Motifs in mtDNA Deletions: Cause or Coincidence?
Deletion mutations within mitochondrial DNA (mtDNA) have been implicated in degenerative and aging related conditions, such as sarcopenia and neuro-degeneration. While the precise molecular mechanism of deletion formation in mtDNA is still not completely understood, genome motifs such as direct repe...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329436/ https://www.ncbi.nlm.nih.gov/pubmed/22529999 http://dx.doi.org/10.1371/journal.pone.0035271 |