Alzheimer's Disease-Linked Mutations in Presenilin-1 Result in a Drastic Loss of Activity in Purified γ-Secretase Complexes

BACKGROUND: Mutations linked to early onset, familial forms of Alzheimer's disease (FAD) are found most frequently in PSEN1, the gene encoding presenilin-1 (PS1). Together with nicastrin (NCT), anterior pharynx-defective protein 1 (APH1), and presenilin enhancer 2 (PEN2), the catalytic subunit...

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Detalles Bibliográficos
Autores principales: Cacquevel, Matthias, Aeschbach, Lorène, Houacine, Jemila, Fraering, Patrick C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329438/
https://www.ncbi.nlm.nih.gov/pubmed/22529981
http://dx.doi.org/10.1371/journal.pone.0035133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329438/
https://www.ncbi.nlm.nih.gov/pubmed/22529981
http://dx.doi.org/10.1371/journal.pone.0035133

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