Alternative Polyadenylation and Nonsense-Mediated Decay Coordinately Regulate the Human HFE mRNA Levels

Nonsense-mediated decay (NMD) is an mRNA surveillance pathway that selectively recognizes and degrades defective mRNAs carrying premature translation-termination codons. However, several studies have shown that NMD also targets physiological transcripts that encode full-length proteins, modulating t...

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Detalles Bibliográficos
Autores principales: Martins, Rute, Proença, Daniela, Silva, Bruno, Barbosa, Cristina, Silva, Ana Luísa, Faustino, Paula, Romão, Luísa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329446/
https://www.ncbi.nlm.nih.gov/pubmed/22530027
http://dx.doi.org/10.1371/journal.pone.0035461

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