Monozygotic twins discordant for constitutive BRCA1 promoter methylation, childhood cancer and secondary cancer

We describe monozygotic twins discordant for childhood leukemia and secondary thyroid carcinoma. We used bisulfite pyrosequencing to compare the constitutive promoter methylation of BRCA1 and several other tumor suppressor genes in primary fibroblasts. The affected twin displayed an increased BRCA1...

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Detalles Bibliográficos
Autores principales: Galetzka, Danuta, Hansmann, Tamara, El Hajj, Nady, Weis, Eva, Irmscher, Benjamin, Ludwig, Marco, Schneider-Rätzke, Brigitte, Kohlschmidt, Nicolai, Beyer, Vera, Bartsch, Oliver, Zechner, Ulrich, Spix, Claudia, Haaf, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329502/
https://www.ncbi.nlm.nih.gov/pubmed/22207351
http://dx.doi.org/10.4161/epi.7.1.18814

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