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Protein High-Force Pulling Simulations Yield Low-Force Results

All-atom explicit-solvent molecular dynamics simulations are used to pull with extremely large constant force (750–3000 pN) on three small proteins. The introduction of a nondimensional timescale permits direct comparison of unfolding across all forces. A crossover force of approximately 1100 pN div...

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Detalles Bibliográficos
Autores principales:	Lichter, Seth, Rafferty, Benjamin, Flohr, Zachary, Martini, Ashlie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329509/ https://www.ncbi.nlm.nih.gov/pubmed/22529933 http://dx.doi.org/10.1371/journal.pone.0034781

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