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Role of the Cellular Prion Protein in Oligodendrocyte Precursor Cell Proliferation and Differentiation in the Developing and Adult Mouse CNS
There are numerous studies describing the signaling mechanisms that mediate oligodendrocyte precursor cell (OPC) proliferation and differentiation, although the contribution of the cellular prion protein (PrP(c)) to this process remains unclear. PrP(c) is a glycosyl-phosphatidylinositol (GPI)-anchor...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329524/ https://www.ncbi.nlm.nih.gov/pubmed/22529900 http://dx.doi.org/10.1371/journal.pone.0033872 |
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author | Bribián, Ana Fontana, Xavier Llorens, Franc Gavín, Rosalina Reina, Manuel García-Verdugo, José Manuel Torres, Juan María de Castro, Fernando del Río, José Antonio |
author_facet | Bribián, Ana Fontana, Xavier Llorens, Franc Gavín, Rosalina Reina, Manuel García-Verdugo, José Manuel Torres, Juan María de Castro, Fernando del Río, José Antonio |
author_sort | Bribián, Ana |
collection | PubMed |
description | There are numerous studies describing the signaling mechanisms that mediate oligodendrocyte precursor cell (OPC) proliferation and differentiation, although the contribution of the cellular prion protein (PrP(c)) to this process remains unclear. PrP(c) is a glycosyl-phosphatidylinositol (GPI)-anchored glycoprotein involved in diverse cellular processes during the development and maturation of the mammalian central nervous system (CNS). Here we describe how PrP(c) influences oligodendrocyte proliferation in the developing and adult CNS. OPCs that lack PrP(c) proliferate more vigorously at the expense of a delay in differentiation, which correlates with changes in the expression of oligodendrocyte lineage markers. In addition, numerous NG2-positive cells were observed in cortical regions of adult PrP(c) knockout mice, although no significant changes in myelination can be seen, probably due to the death of surplus cells. |
format | Online Article Text |
id | pubmed-3329524 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-33295242012-04-23 Role of the Cellular Prion Protein in Oligodendrocyte Precursor Cell Proliferation and Differentiation in the Developing and Adult Mouse CNS Bribián, Ana Fontana, Xavier Llorens, Franc Gavín, Rosalina Reina, Manuel García-Verdugo, José Manuel Torres, Juan María de Castro, Fernando del Río, José Antonio PLoS One Research Article There are numerous studies describing the signaling mechanisms that mediate oligodendrocyte precursor cell (OPC) proliferation and differentiation, although the contribution of the cellular prion protein (PrP(c)) to this process remains unclear. PrP(c) is a glycosyl-phosphatidylinositol (GPI)-anchored glycoprotein involved in diverse cellular processes during the development and maturation of the mammalian central nervous system (CNS). Here we describe how PrP(c) influences oligodendrocyte proliferation in the developing and adult CNS. OPCs that lack PrP(c) proliferate more vigorously at the expense of a delay in differentiation, which correlates with changes in the expression of oligodendrocyte lineage markers. In addition, numerous NG2-positive cells were observed in cortical regions of adult PrP(c) knockout mice, although no significant changes in myelination can be seen, probably due to the death of surplus cells. Public Library of Science 2012-04-18 /pmc/articles/PMC3329524/ /pubmed/22529900 http://dx.doi.org/10.1371/journal.pone.0033872 Text en Bribián et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Bribián, Ana Fontana, Xavier Llorens, Franc Gavín, Rosalina Reina, Manuel García-Verdugo, José Manuel Torres, Juan María de Castro, Fernando del Río, José Antonio Role of the Cellular Prion Protein in Oligodendrocyte Precursor Cell Proliferation and Differentiation in the Developing and Adult Mouse CNS |
title | Role of the Cellular Prion Protein in Oligodendrocyte Precursor Cell Proliferation and Differentiation in the Developing and Adult Mouse CNS |
title_full | Role of the Cellular Prion Protein in Oligodendrocyte Precursor Cell Proliferation and Differentiation in the Developing and Adult Mouse CNS |
title_fullStr | Role of the Cellular Prion Protein in Oligodendrocyte Precursor Cell Proliferation and Differentiation in the Developing and Adult Mouse CNS |
title_full_unstemmed | Role of the Cellular Prion Protein in Oligodendrocyte Precursor Cell Proliferation and Differentiation in the Developing and Adult Mouse CNS |
title_short | Role of the Cellular Prion Protein in Oligodendrocyte Precursor Cell Proliferation and Differentiation in the Developing and Adult Mouse CNS |
title_sort | role of the cellular prion protein in oligodendrocyte precursor cell proliferation and differentiation in the developing and adult mouse cns |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329524/ https://www.ncbi.nlm.nih.gov/pubmed/22529900 http://dx.doi.org/10.1371/journal.pone.0033872 |
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