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Signaling-Mediated Bacterial Persister Formation

Here we show that bacterial communication through indole signaling induces persistence, a phenomenon in which a subset of an isogenic bacterial population tolerates antibiotic treatment. We monitor indole-induced persister formation using microfluidics, and identify the role of oxidative stress and...

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Detalles Bibliográficos
Autores principales: Vega, Nicole M., Allison, Kyle R., Khalil, Ahmad S., Collins, James J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329571/
https://www.ncbi.nlm.nih.gov/pubmed/22426114
http://dx.doi.org/10.1038/nchembio.915
Descripción
Sumario:Here we show that bacterial communication through indole signaling induces persistence, a phenomenon in which a subset of an isogenic bacterial population tolerates antibiotic treatment. We monitor indole-induced persister formation using microfluidics, and identify the role of oxidative stress and phage-shock pathways in this phenomenon. We propose a model in which indole signaling “inoculates” a bacterial sub-population against antibiotics by activating stress responses, leading to persister formation.