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Proteomic Technologies for the Study of Osteosarcoma
Osteosarcoma is the most common primary bone cancer of children and is established during stages of rapid bone growth. The disease is a consequence of immature osteoblast differentiation, which gives way to a rapidly synthesized incompletely mineralized and disorganized bone matrix. The mechanism of...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329661/ https://www.ncbi.nlm.nih.gov/pubmed/22550414 http://dx.doi.org/10.1155/2012/169416 |
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author | Byrum, Stephanie D. Washam, Charity L. Montgomery, Corey O. Tackett, Alan J. Suva, Larry J. |
author_facet | Byrum, Stephanie D. Washam, Charity L. Montgomery, Corey O. Tackett, Alan J. Suva, Larry J. |
author_sort | Byrum, Stephanie D. |
collection | PubMed |
description | Osteosarcoma is the most common primary bone cancer of children and is established during stages of rapid bone growth. The disease is a consequence of immature osteoblast differentiation, which gives way to a rapidly synthesized incompletely mineralized and disorganized bone matrix. The mechanism of osteosarcoma tumorogenesis is poorly understood, and few proteomic studies have been used to interrogate the disease thus far. Accordingly, these studies have identified proteins that have been known to be associated with other malignancies, rather than being osteosarcoma specific. In this paper, we focus on the growing list of available state-of-the-art proteomic technologies and their specific application to the discovery of novel osteosarcoma diagnostic and therapeutic targets. The current signaling markers/pathways associated with primary and metastatic osteosarcoma that have been identified by early-stage proteomic technologies thus far are also described. |
format | Online Article Text |
id | pubmed-3329661 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33296612012-05-01 Proteomic Technologies for the Study of Osteosarcoma Byrum, Stephanie D. Washam, Charity L. Montgomery, Corey O. Tackett, Alan J. Suva, Larry J. Sarcoma Review Article Osteosarcoma is the most common primary bone cancer of children and is established during stages of rapid bone growth. The disease is a consequence of immature osteoblast differentiation, which gives way to a rapidly synthesized incompletely mineralized and disorganized bone matrix. The mechanism of osteosarcoma tumorogenesis is poorly understood, and few proteomic studies have been used to interrogate the disease thus far. Accordingly, these studies have identified proteins that have been known to be associated with other malignancies, rather than being osteosarcoma specific. In this paper, we focus on the growing list of available state-of-the-art proteomic technologies and their specific application to the discovery of novel osteosarcoma diagnostic and therapeutic targets. The current signaling markers/pathways associated with primary and metastatic osteosarcoma that have been identified by early-stage proteomic technologies thus far are also described. Hindawi Publishing Corporation 2012 2012-03-06 /pmc/articles/PMC3329661/ /pubmed/22550414 http://dx.doi.org/10.1155/2012/169416 Text en Copyright © 2012 Stephanie D. Byrum et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Byrum, Stephanie D. Washam, Charity L. Montgomery, Corey O. Tackett, Alan J. Suva, Larry J. Proteomic Technologies for the Study of Osteosarcoma |
title | Proteomic Technologies for the Study of Osteosarcoma |
title_full | Proteomic Technologies for the Study of Osteosarcoma |
title_fullStr | Proteomic Technologies for the Study of Osteosarcoma |
title_full_unstemmed | Proteomic Technologies for the Study of Osteosarcoma |
title_short | Proteomic Technologies for the Study of Osteosarcoma |
title_sort | proteomic technologies for the study of osteosarcoma |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329661/ https://www.ncbi.nlm.nih.gov/pubmed/22550414 http://dx.doi.org/10.1155/2012/169416 |
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