Cargando…
Association of Diabetes and HbA(1c) Levels With Gastrointestinal Manifestations
OBJECTIVE: To determine the prevalence of gastrointestinal (GI) manifestations associated with diabetes mellitus (DM) in a Taiwanese population undergoing bidirectional endoscopies. RESEARCH DESIGN AND METHODS: Subjects voluntarily undergoing upper endoscopy/colonoscopy as part of a medical examinat...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329853/ https://www.ncbi.nlm.nih.gov/pubmed/22410812 http://dx.doi.org/10.2337/dc11-1596 |
_version_ | 1782229903056306176 |
---|---|
author | Tseng, Ping-Huei Lee, Yi-Chia Chiu, Han-Mo Chen, Chien-Chuan Liao, Wei-Chih Tu, Chia-Hung Yang, Wei-Shiung Wu, Ming-Shiang |
author_facet | Tseng, Ping-Huei Lee, Yi-Chia Chiu, Han-Mo Chen, Chien-Chuan Liao, Wei-Chih Tu, Chia-Hung Yang, Wei-Shiung Wu, Ming-Shiang |
author_sort | Tseng, Ping-Huei |
collection | PubMed |
description | OBJECTIVE: To determine the prevalence of gastrointestinal (GI) manifestations associated with diabetes mellitus (DM) in a Taiwanese population undergoing bidirectional endoscopies. RESEARCH DESIGN AND METHODS: Subjects voluntarily undergoing upper endoscopy/colonoscopy as part of a medical examination at the National Taiwan University Hospital were recruited during 2009. Diagnosis of DM included past history of DM, fasting plasma glucose ≥126 mg/dL, or glycated hemoglobin (HbA(1c)) ≥6.5%. Comparisons were made between diabetic and nondiabetic subjects, subjects with lower and higher HbA(1c) levels, and diabetic subjects with and without complications, respectively, for their GI symptoms, noninvasive GI testing results, and endoscopic findings. RESULTS: Among 7,770 study subjects, 722 (9.3%) were diagnosed with DM. The overall prevalence of GI symptoms was lower in DM subjects (30.3 vs. 35.4%, P = 0.006). In contrast, the prevalence of erosive esophagitis (34.3 vs. 28.6%, P = 0.002), Barrett's esophagus (0.6 vs. 0.1%, P = 0.001), peptic ulcer disease (14.8 vs. 8.5%, P < 0.001), gastric neoplasms (1.8 vs. 0.7%, P = 0.003), and colonic neoplasms (26.6 vs. 16.5%, P < 0.001) was higher in diabetic subjects. Diagnostic accuracy of immunochemical fecal occult blood test for colonic neoplasms was significantly decreased in DM (70.7 vs. 81.7%, P < 0.001). Higher HbA(1c) levels were associated with a decrease of GI symptoms and an increase of endoscopic abnormalities. Diabetic subjects with complications had a higher prevalence of colonic neoplasms (39.2 vs. 24.5%, P = 0.002) than those without. CONCLUSIONS: DM and higher levels of HbA(1c) were associated with lower prevalence of GI symptoms but higher prevalence of endoscopic abnormalities. |
format | Online Article Text |
id | pubmed-3329853 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-33298532013-05-01 Association of Diabetes and HbA(1c) Levels With Gastrointestinal Manifestations Tseng, Ping-Huei Lee, Yi-Chia Chiu, Han-Mo Chen, Chien-Chuan Liao, Wei-Chih Tu, Chia-Hung Yang, Wei-Shiung Wu, Ming-Shiang Diabetes Care Original Research OBJECTIVE: To determine the prevalence of gastrointestinal (GI) manifestations associated with diabetes mellitus (DM) in a Taiwanese population undergoing bidirectional endoscopies. RESEARCH DESIGN AND METHODS: Subjects voluntarily undergoing upper endoscopy/colonoscopy as part of a medical examination at the National Taiwan University Hospital were recruited during 2009. Diagnosis of DM included past history of DM, fasting plasma glucose ≥126 mg/dL, or glycated hemoglobin (HbA(1c)) ≥6.5%. Comparisons were made between diabetic and nondiabetic subjects, subjects with lower and higher HbA(1c) levels, and diabetic subjects with and without complications, respectively, for their GI symptoms, noninvasive GI testing results, and endoscopic findings. RESULTS: Among 7,770 study subjects, 722 (9.3%) were diagnosed with DM. The overall prevalence of GI symptoms was lower in DM subjects (30.3 vs. 35.4%, P = 0.006). In contrast, the prevalence of erosive esophagitis (34.3 vs. 28.6%, P = 0.002), Barrett's esophagus (0.6 vs. 0.1%, P = 0.001), peptic ulcer disease (14.8 vs. 8.5%, P < 0.001), gastric neoplasms (1.8 vs. 0.7%, P = 0.003), and colonic neoplasms (26.6 vs. 16.5%, P < 0.001) was higher in diabetic subjects. Diagnostic accuracy of immunochemical fecal occult blood test for colonic neoplasms was significantly decreased in DM (70.7 vs. 81.7%, P < 0.001). Higher HbA(1c) levels were associated with a decrease of GI symptoms and an increase of endoscopic abnormalities. Diabetic subjects with complications had a higher prevalence of colonic neoplasms (39.2 vs. 24.5%, P = 0.002) than those without. CONCLUSIONS: DM and higher levels of HbA(1c) were associated with lower prevalence of GI symptoms but higher prevalence of endoscopic abnormalities. American Diabetes Association 2012-05 2012-04-11 /pmc/articles/PMC3329853/ /pubmed/22410812 http://dx.doi.org/10.2337/dc11-1596 Text en © 2012 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. |
spellingShingle | Original Research Tseng, Ping-Huei Lee, Yi-Chia Chiu, Han-Mo Chen, Chien-Chuan Liao, Wei-Chih Tu, Chia-Hung Yang, Wei-Shiung Wu, Ming-Shiang Association of Diabetes and HbA(1c) Levels With Gastrointestinal Manifestations |
title | Association of Diabetes and HbA(1c) Levels With Gastrointestinal Manifestations |
title_full | Association of Diabetes and HbA(1c) Levels With Gastrointestinal Manifestations |
title_fullStr | Association of Diabetes and HbA(1c) Levels With Gastrointestinal Manifestations |
title_full_unstemmed | Association of Diabetes and HbA(1c) Levels With Gastrointestinal Manifestations |
title_short | Association of Diabetes and HbA(1c) Levels With Gastrointestinal Manifestations |
title_sort | association of diabetes and hba(1c) levels with gastrointestinal manifestations |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329853/ https://www.ncbi.nlm.nih.gov/pubmed/22410812 http://dx.doi.org/10.2337/dc11-1596 |
work_keys_str_mv | AT tsengpinghuei associationofdiabetesandhba1clevelswithgastrointestinalmanifestations AT leeyichia associationofdiabetesandhba1clevelswithgastrointestinalmanifestations AT chiuhanmo associationofdiabetesandhba1clevelswithgastrointestinalmanifestations AT chenchienchuan associationofdiabetesandhba1clevelswithgastrointestinalmanifestations AT liaoweichih associationofdiabetesandhba1clevelswithgastrointestinalmanifestations AT tuchiahung associationofdiabetesandhba1clevelswithgastrointestinalmanifestations AT yangweishiung associationofdiabetesandhba1clevelswithgastrointestinalmanifestations AT wumingshiang associationofdiabetesandhba1clevelswithgastrointestinalmanifestations |