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Metastatic Patterns of Myxoid/Round Cell Liposarcoma: A Review of a 25-Year Experience

Myxoid/round cell liposarcoma (MRCL), unlike other soft tissue sarcomas, has been associated with unusual pattern of metastasis to extrapulmonary sites. In an attempt to elucidate the clinical features of MRCL with metastatic lesions, 58 cases, from the medical database of Keio University Hospital w...

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Autores principales: Asano, Naofumi, Susa, Michiro, Hosaka, Seiichi, Nakayama, Robert, Kobayashi, Eisuke, Takeuchi, Katsuhito, Horiuchi, Keisuke, Suzuki, Yoshihisa, Anazawa, Ukei, Mukai, Makio, Toyama, Yoshiaki, Yabe, Hiroo, Morioka, Hideo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329861/
https://www.ncbi.nlm.nih.gov/pubmed/22550416
http://dx.doi.org/10.1155/2012/345161
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author Asano, Naofumi
Susa, Michiro
Hosaka, Seiichi
Nakayama, Robert
Kobayashi, Eisuke
Takeuchi, Katsuhito
Horiuchi, Keisuke
Suzuki, Yoshihisa
Anazawa, Ukei
Mukai, Makio
Toyama, Yoshiaki
Yabe, Hiroo
Morioka, Hideo
author_facet Asano, Naofumi
Susa, Michiro
Hosaka, Seiichi
Nakayama, Robert
Kobayashi, Eisuke
Takeuchi, Katsuhito
Horiuchi, Keisuke
Suzuki, Yoshihisa
Anazawa, Ukei
Mukai, Makio
Toyama, Yoshiaki
Yabe, Hiroo
Morioka, Hideo
author_sort Asano, Naofumi
collection PubMed
description Myxoid/round cell liposarcoma (MRCL), unlike other soft tissue sarcomas, has been associated with unusual pattern of metastasis to extrapulmonary sites. In an attempt to elucidate the clinical features of MRCL with metastatic lesions, 58 cases, from the medical database of Keio University Hospital were used for the evaluation. 47 patients (81%) had no metastases, whereas 11 patients (11%) had metastases during their clinical course. Among the 11 patients with metastatic lesions, 8 patients (73%) had extrapulmonary metastases and 3 patients (27%) had pulmonary metastases. Patients were further divided into three groups; without metastasis, with extrapulmonary metastasis, and with pulmonary metastasis. When the metastatic patterns were stratified according to tumor size, there was statistical significance between the three groups (P = 0.028). The 8 cases with extrapulmonary metastases were all larger than 10 cm. Similarly, histological grading had a significant impact on metastatic patterns (P = 0.027). 3 cases with pulmonary metastatic lesions were all diagnosed as high grade. In conclusion, large size and low histological grade were significantly associated with extrapulmonary metastasis.
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spelling pubmed-33298612012-05-01 Metastatic Patterns of Myxoid/Round Cell Liposarcoma: A Review of a 25-Year Experience Asano, Naofumi Susa, Michiro Hosaka, Seiichi Nakayama, Robert Kobayashi, Eisuke Takeuchi, Katsuhito Horiuchi, Keisuke Suzuki, Yoshihisa Anazawa, Ukei Mukai, Makio Toyama, Yoshiaki Yabe, Hiroo Morioka, Hideo Sarcoma Clinical Study Myxoid/round cell liposarcoma (MRCL), unlike other soft tissue sarcomas, has been associated with unusual pattern of metastasis to extrapulmonary sites. In an attempt to elucidate the clinical features of MRCL with metastatic lesions, 58 cases, from the medical database of Keio University Hospital were used for the evaluation. 47 patients (81%) had no metastases, whereas 11 patients (11%) had metastases during their clinical course. Among the 11 patients with metastatic lesions, 8 patients (73%) had extrapulmonary metastases and 3 patients (27%) had pulmonary metastases. Patients were further divided into three groups; without metastasis, with extrapulmonary metastasis, and with pulmonary metastasis. When the metastatic patterns were stratified according to tumor size, there was statistical significance between the three groups (P = 0.028). The 8 cases with extrapulmonary metastases were all larger than 10 cm. Similarly, histological grading had a significant impact on metastatic patterns (P = 0.027). 3 cases with pulmonary metastatic lesions were all diagnosed as high grade. In conclusion, large size and low histological grade were significantly associated with extrapulmonary metastasis. Hindawi Publishing Corporation 2012 2012-04-01 /pmc/articles/PMC3329861/ /pubmed/22550416 http://dx.doi.org/10.1155/2012/345161 Text en Copyright © 2012 Naofumi Asano et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Asano, Naofumi
Susa, Michiro
Hosaka, Seiichi
Nakayama, Robert
Kobayashi, Eisuke
Takeuchi, Katsuhito
Horiuchi, Keisuke
Suzuki, Yoshihisa
Anazawa, Ukei
Mukai, Makio
Toyama, Yoshiaki
Yabe, Hiroo
Morioka, Hideo
Metastatic Patterns of Myxoid/Round Cell Liposarcoma: A Review of a 25-Year Experience
title Metastatic Patterns of Myxoid/Round Cell Liposarcoma: A Review of a 25-Year Experience
title_full Metastatic Patterns of Myxoid/Round Cell Liposarcoma: A Review of a 25-Year Experience
title_fullStr Metastatic Patterns of Myxoid/Round Cell Liposarcoma: A Review of a 25-Year Experience
title_full_unstemmed Metastatic Patterns of Myxoid/Round Cell Liposarcoma: A Review of a 25-Year Experience
title_short Metastatic Patterns of Myxoid/Round Cell Liposarcoma: A Review of a 25-Year Experience
title_sort metastatic patterns of myxoid/round cell liposarcoma: a review of a 25-year experience
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329861/
https://www.ncbi.nlm.nih.gov/pubmed/22550416
http://dx.doi.org/10.1155/2012/345161
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