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Ligand-Dependent Conformations and Dynamics of the Serotonin 5-HT(2A) Receptor Determine Its Activation and Membrane-Driven Oligomerization Properties

From computational simulations of a serotonin 2A receptor (5-HT(2A)R) model complexed with pharmacologically and structurally diverse ligands we identify different conformational states and dynamics adopted by the receptor bound to the full agonist 5-HT, the partial agonist LSD, and the inverse agon...

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Detalles Bibliográficos
Autores principales:	Shan, Jufang, Khelashvili, George, Mondal, Sayan, Mehler, Ernest L., Weinstein, Harel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3330085/ https://www.ncbi.nlm.nih.gov/pubmed/22532793 http://dx.doi.org/10.1371/journal.pcbi.1002473

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