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Computational Design of a PDZ Domain Peptide Inhibitor that Rescues CFTR Activity

The cystic fibrosis transmembrane conductance regulator (CFTR) is an epithelial chloride channel mutated in patients with cystic fibrosis (CF). The most prevalent CFTR mutation, ΔF508, blocks folding in the endoplasmic reticulum. Recent work has shown that some ΔF508-CFTR channel activity can be rec...

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Detalles Bibliográficos
Autores principales:	Roberts, Kyle E., Cushing, Patrick R., Boisguerin, Prisca, Madden, Dean R., Donald, Bruce R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3330111/ https://www.ncbi.nlm.nih.gov/pubmed/22532795 http://dx.doi.org/10.1371/journal.pcbi.1002477

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