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Extracellular Signal-Regulated Kinases Modulate DNA Damage Response - A Contributing Factor to Using MEK Inhibitors in Cancer Therapy

The Raf-MEK-ERK pathway is commonly activated in human cancers, largely attributable to the extracellular signal-regulated kinases (ERKs) being a common downstream target of growth factor receptors, Ras, and Raf. Elevation of these up-stream signals occurs frequently in a variety of malignancies and...

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Detalles Bibliográficos
Autores principales:	Wei, F, Yan, J, Tang, D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bentham Science Publishers 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3330700/ https://www.ncbi.nlm.nih.gov/pubmed/22087839 http://dx.doi.org/10.2174/092986711798194388

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