BIOEFFICIENCY OF INDIGOGERA TINCTORIA LINN. ON ISONIAZID INDUCED HEPATOTOXICITY IN ALBINORATS

Indigofera tincoria leaf extract has been evaluated for its anti-hepatotoxic activity on Rats. Isoniazid is a first line agent for treatment of tuberculosis. Acute ingestion by adults with little dose can lead to mild liver toxicity. In our study, administration of isoniazid (100mg/Kg of the body weight) to normal albino rats for 15 days, results in the induction of hepatitis, which is reversed by the leaf extract of Indigofera tincoria. Two different dose volumes of Indigofera tincoria (5ml/kg of the body weight and 10ml/kg of body weight) were given to determine the hepatoprotective efficacy. The effect of the extract was found to be dose dependent and the altered levels of AST, ALT, ALP and other serum parameters such as total protein, total bilirubin are showing normal values. Indigofera tinctoria provided significant protection against most of the biochemical alterations produced by isoniazid in test animals