ANTIULCER ACTIVITY OF PIPAL EXTRACT

An ethanol extract of Pipal has been studied for its ability to inhibit gastric acidity and to protect gastric mucosa against the injuries caused by pyloric ligation, acetyl salicylic acid and cytodestructing agents (80% ethanol, 06M Hcl and 0.2 M Hcl) in rats. The results of this study demonstrate that ethanol extract of papal has significant effects on various experimentally induced ulcers. It reduced significantly the intensity of gastric lesions induced by pylorus ligation, acetyl salicylic cid (ASA) and mucosal damaging agents. Also the total acidity was found to be decreased Acutic toxicity testis shoed no toxic symptoms or mortality over a period of 7 days with doses 0.25-1.5 gm/kg. These findings suggests that ethanol extract of papal exerts anticulcer effects by increasing gastric mucosal resistance and cyto-protective activities.