AN IN VITRO STUDY ON THE ANTIMICROBIAL EFFECT OF SELECT HETEROCYCLIC NITROGEN COMPOUNDS

In vitro antimicrobial activity of seventeen heterocyclic nitrogen compounds {2-substituted pyrido [1,2-a] pyrimidin -4-oxo-1 [4]-3-Carbonitriles and ethyl 5-amino-3-(substituted) - pyrazole-3-Carboxylates} was tested against Escherichia coli, Bacillus subtilis and candida albicans strains, Antimicr...

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Detalles Bibliográficos
Autores principales: Reddy, Y.S.R., Venkatesh, Sama, Misra, Uma Shankar, Suresh, B., Azam, Md Afzal, Sethuraman, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 1995
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331202/
https://www.ncbi.nlm.nih.gov/pubmed/22556732
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author Reddy, Y.S.R.
Venkatesh, Sama
Misra, Uma Shankar
Suresh, B.
Azam, Md Afzal
Sethuraman, M
author_facet Reddy, Y.S.R.
Venkatesh, Sama
Misra, Uma Shankar
Suresh, B.
Azam, Md Afzal
Sethuraman, M
author_sort Reddy, Y.S.R.
collection PubMed
description In vitro antimicrobial activity of seventeen heterocyclic nitrogen compounds {2-substituted pyrido [1,2-a] pyrimidin -4-oxo-1 [4]-3-Carbonitriles and ethyl 5-amino-3-(substituted) - pyrazole-3-Carboxylates} was tested against Escherichia coli, Bacillus subtilis and candida albicans strains, Antimicrobial activity was measured using standard two -fold serial dilution method and the minimum inhibitory concentration (MIC) values are determined, The MIC of pyrazoles and pyrido[1,2 -a] pyrimidines are found to be 25 μg/ml to 50 μg/ml against E. Coli and 50 μg/ml against B.subtilis respectively. Both pyrazole and pyrido [1,2-a] Pyrimidines are found to be totally ineffective against C. albicans.
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spelling pubmed-33312022012-04-27 AN IN VITRO STUDY ON THE ANTIMICROBIAL EFFECT OF SELECT HETEROCYCLIC NITROGEN COMPOUNDS Reddy, Y.S.R. Venkatesh, Sama Misra, Uma Shankar Suresh, B. Azam, Md Afzal Sethuraman, M Anc Sci Life Original Article In vitro antimicrobial activity of seventeen heterocyclic nitrogen compounds {2-substituted pyrido [1,2-a] pyrimidin -4-oxo-1 [4]-3-Carbonitriles and ethyl 5-amino-3-(substituted) - pyrazole-3-Carboxylates} was tested against Escherichia coli, Bacillus subtilis and candida albicans strains, Antimicrobial activity was measured using standard two -fold serial dilution method and the minimum inhibitory concentration (MIC) values are determined, The MIC of pyrazoles and pyrido[1,2 -a] pyrimidines are found to be 25 μg/ml to 50 μg/ml against E. Coli and 50 μg/ml against B.subtilis respectively. Both pyrazole and pyrido [1,2-a] Pyrimidines are found to be totally ineffective against C. albicans. Medknow Publications & Media Pvt Ltd 1995 /pmc/articles/PMC3331202/ /pubmed/22556732 Text en Copyright: © Ancient Science of Life http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Reddy, Y.S.R.
Venkatesh, Sama
Misra, Uma Shankar
Suresh, B.
Azam, Md Afzal
Sethuraman, M
AN IN VITRO STUDY ON THE ANTIMICROBIAL EFFECT OF SELECT HETEROCYCLIC NITROGEN COMPOUNDS
title AN IN VITRO STUDY ON THE ANTIMICROBIAL EFFECT OF SELECT HETEROCYCLIC NITROGEN COMPOUNDS
title_full AN IN VITRO STUDY ON THE ANTIMICROBIAL EFFECT OF SELECT HETEROCYCLIC NITROGEN COMPOUNDS
title_fullStr AN IN VITRO STUDY ON THE ANTIMICROBIAL EFFECT OF SELECT HETEROCYCLIC NITROGEN COMPOUNDS
title_full_unstemmed AN IN VITRO STUDY ON THE ANTIMICROBIAL EFFECT OF SELECT HETEROCYCLIC NITROGEN COMPOUNDS
title_short AN IN VITRO STUDY ON THE ANTIMICROBIAL EFFECT OF SELECT HETEROCYCLIC NITROGEN COMPOUNDS
title_sort in vitro study on the antimicrobial effect of select heterocyclic nitrogen compounds
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331202/
https://www.ncbi.nlm.nih.gov/pubmed/22556732
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