FURTHER ON THE PHARMACOLOGY OF TRICHOPUS ZEYLANICUS

Oral administration of Trichopus zeylanicus to mice (0.5 ml of 2% water suspension / mouse) for 7 consecutive days markedly increased the number of thymocytes splenic lymphocytes, total blood leucocytes and peritoneal macrophages without any effect on Haemoglobin content and body weight. This increa...

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Detalles Bibliográficos
Autores principales: Pushpangadan, P., Rajasekharan, S., Subramaniam, A., Latha, P.G., Evans, D.A., Raj, R. Valsa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 1995
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331231/
https://www.ncbi.nlm.nih.gov/pubmed/22556689
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author Pushpangadan, P.
Rajasekharan, S.
Subramaniam, A.
Latha, P.G.
Evans, D.A.
Raj, R. Valsa
author_facet Pushpangadan, P.
Rajasekharan, S.
Subramaniam, A.
Latha, P.G.
Evans, D.A.
Raj, R. Valsa
author_sort Pushpangadan, P.
collection PubMed
description Oral administration of Trichopus zeylanicus to mice (0.5 ml of 2% water suspension / mouse) for 7 consecutive days markedly increased the number of thymocytes splenic lymphocytes, total blood leucocytes and peritoneal macrophages without any effect on Haemoglobin content and body weight. This increase in the proliferation of lymphocytes and macrophages could be one of the mechanism of T.zeylanicus induced immunomodulation. Treatment with T. zeylanicus protected mice from tumour cell growth when challenged with 0.5 million of EAC ascetic tumour cells / mouse. Studies on the gastrointestinal function of this drug showed that the drug slightly reduced intestinal motility as judged from charcoal movement.
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spelling pubmed-33312312012-04-27 FURTHER ON THE PHARMACOLOGY OF TRICHOPUS ZEYLANICUS Pushpangadan, P. Rajasekharan, S. Subramaniam, A. Latha, P.G. Evans, D.A. Raj, R. Valsa Anc Sci Life Original Article Oral administration of Trichopus zeylanicus to mice (0.5 ml of 2% water suspension / mouse) for 7 consecutive days markedly increased the number of thymocytes splenic lymphocytes, total blood leucocytes and peritoneal macrophages without any effect on Haemoglobin content and body weight. This increase in the proliferation of lymphocytes and macrophages could be one of the mechanism of T.zeylanicus induced immunomodulation. Treatment with T. zeylanicus protected mice from tumour cell growth when challenged with 0.5 million of EAC ascetic tumour cells / mouse. Studies on the gastrointestinal function of this drug showed that the drug slightly reduced intestinal motility as judged from charcoal movement. Medknow Publications & Media Pvt Ltd 1995 /pmc/articles/PMC3331231/ /pubmed/22556689 Text en Copyright: © Ancient Science of Life http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Pushpangadan, P.
Rajasekharan, S.
Subramaniam, A.
Latha, P.G.
Evans, D.A.
Raj, R. Valsa
FURTHER ON THE PHARMACOLOGY OF TRICHOPUS ZEYLANICUS
title FURTHER ON THE PHARMACOLOGY OF TRICHOPUS ZEYLANICUS
title_full FURTHER ON THE PHARMACOLOGY OF TRICHOPUS ZEYLANICUS
title_fullStr FURTHER ON THE PHARMACOLOGY OF TRICHOPUS ZEYLANICUS
title_full_unstemmed FURTHER ON THE PHARMACOLOGY OF TRICHOPUS ZEYLANICUS
title_short FURTHER ON THE PHARMACOLOGY OF TRICHOPUS ZEYLANICUS
title_sort further on the pharmacology of trichopus zeylanicus
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331231/
https://www.ncbi.nlm.nih.gov/pubmed/22556689
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