EFFECT OF NIMBIDIN ON GASTRIC ACID SECRETION

Nimbidin, the crude bitter compound from neem has been investigated for its gastric anti secretory activity in rats and cats. It exhibited significant anti – secretory activity in pylorus ligated rats and cats. In lumen – perfused rats it suppressed the basal as well as histamine and carbachol stimu...

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Detalles Bibliográficos
Autores principales: Pillai, N. R., Santhakumari, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 1985
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331449/
https://www.ncbi.nlm.nih.gov/pubmed/22557506
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author Pillai, N. R.
Santhakumari, G.
author_facet Pillai, N. R.
Santhakumari, G.
author_sort Pillai, N. R.
collection PubMed
description Nimbidin, the crude bitter compound from neem has been investigated for its gastric anti secretory activity in rats and cats. It exhibited significant anti – secretory activity in pylorus ligated rats and cats. In lumen – perfused rats it suppressed the basal as well as histamine and carbachol stimulated gastric acid output at 40 mg/kg (i.v). However it had no effect on ASA – induced back – diffusion of H+ ions. This anti secretory activity of nimbidin was found to be similar to that of H2 – receptor antagonists, which are reported to suppress the histamine induced gastric secretion in animals and man.
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spelling pubmed-33314492012-04-27 EFFECT OF NIMBIDIN ON GASTRIC ACID SECRETION Pillai, N. R. Santhakumari, G. Anc Sci Life Original Article Nimbidin, the crude bitter compound from neem has been investigated for its gastric anti secretory activity in rats and cats. It exhibited significant anti – secretory activity in pylorus ligated rats and cats. In lumen – perfused rats it suppressed the basal as well as histamine and carbachol stimulated gastric acid output at 40 mg/kg (i.v). However it had no effect on ASA – induced back – diffusion of H+ ions. This anti secretory activity of nimbidin was found to be similar to that of H2 – receptor antagonists, which are reported to suppress the histamine induced gastric secretion in animals and man. Medknow Publications & Media Pvt Ltd 1985 /pmc/articles/PMC3331449/ /pubmed/22557506 Text en Copyright: © Ancient Science of Life http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Pillai, N. R.
Santhakumari, G.
EFFECT OF NIMBIDIN ON GASTRIC ACID SECRETION
title EFFECT OF NIMBIDIN ON GASTRIC ACID SECRETION
title_full EFFECT OF NIMBIDIN ON GASTRIC ACID SECRETION
title_fullStr EFFECT OF NIMBIDIN ON GASTRIC ACID SECRETION
title_full_unstemmed EFFECT OF NIMBIDIN ON GASTRIC ACID SECRETION
title_short EFFECT OF NIMBIDIN ON GASTRIC ACID SECRETION
title_sort effect of nimbidin on gastric acid secretion
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331449/
https://www.ncbi.nlm.nih.gov/pubmed/22557506
work_keys_str_mv AT pillainr effectofnimbidinongastricacidsecretion
AT santhakumarig effectofnimbidinongastricacidsecretion

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