SOME PHARMACOLOGICAL ACTIONS OF ‘NIMBIDIN’- A BITTER PRINCIPLE OF AZADIRACHTA INDICA-A JUSS (NEEM)

Nimbidin the major bitter principle from oil of seeds of Azadirachta indica A. Juss was investigated for various pharmacological actions in a number animal models. On central nervous system it exhibited moderate sedative effect it did not show any significant cardiovascular effects in experimental a...

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Detalles Bibliográficos
Autores principales: Pillai, N.R., Santhakumari, G., Laping, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 1984
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331505/
https://www.ncbi.nlm.nih.gov/pubmed/22557456
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author Pillai, N.R.
Santhakumari, G.
Laping, Johannes
author_facet Pillai, N.R.
Santhakumari, G.
Laping, Johannes
author_sort Pillai, N.R.
collection PubMed
description Nimbidin the major bitter principle from oil of seeds of Azadirachta indica A. Juss was investigated for various pharmacological actions in a number animal models. On central nervous system it exhibited moderate sedative effect it did not show any significant cardiovascular effects in experimental animals. Autonomic pharmacological studies (in-vitro) revealed pronounced anticholinergic antihistaminic (H1-receptor), anti 5 HT and antinicotinic activities. But in-vivo tests did not show any anticholinergic or anti-histaminic activity. Nimbidin possessed moderate diuretic activity and was found to be devoid of local anaesthetic and antiandrogenic effects in rodents
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spelling pubmed-33315052012-04-27 SOME PHARMACOLOGICAL ACTIONS OF ‘NIMBIDIN’- A BITTER PRINCIPLE OF AZADIRACHTA INDICA-A JUSS (NEEM) Pillai, N.R. Santhakumari, G. Laping, Johannes Anc Sci Life Original Article Nimbidin the major bitter principle from oil of seeds of Azadirachta indica A. Juss was investigated for various pharmacological actions in a number animal models. On central nervous system it exhibited moderate sedative effect it did not show any significant cardiovascular effects in experimental animals. Autonomic pharmacological studies (in-vitro) revealed pronounced anticholinergic antihistaminic (H1-receptor), anti 5 HT and antinicotinic activities. But in-vivo tests did not show any anticholinergic or anti-histaminic activity. Nimbidin possessed moderate diuretic activity and was found to be devoid of local anaesthetic and antiandrogenic effects in rodents Medknow Publications & Media Pvt Ltd 1984 /pmc/articles/PMC3331505/ /pubmed/22557456 Text en Copyright: © Ancient Science of Life http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Pillai, N.R.
Santhakumari, G.
Laping, Johannes
SOME PHARMACOLOGICAL ACTIONS OF ‘NIMBIDIN’- A BITTER PRINCIPLE OF AZADIRACHTA INDICA-A JUSS (NEEM)
title SOME PHARMACOLOGICAL ACTIONS OF ‘NIMBIDIN’- A BITTER PRINCIPLE OF AZADIRACHTA INDICA-A JUSS (NEEM)
title_full SOME PHARMACOLOGICAL ACTIONS OF ‘NIMBIDIN’- A BITTER PRINCIPLE OF AZADIRACHTA INDICA-A JUSS (NEEM)
title_fullStr SOME PHARMACOLOGICAL ACTIONS OF ‘NIMBIDIN’- A BITTER PRINCIPLE OF AZADIRACHTA INDICA-A JUSS (NEEM)
title_full_unstemmed SOME PHARMACOLOGICAL ACTIONS OF ‘NIMBIDIN’- A BITTER PRINCIPLE OF AZADIRACHTA INDICA-A JUSS (NEEM)
title_short SOME PHARMACOLOGICAL ACTIONS OF ‘NIMBIDIN’- A BITTER PRINCIPLE OF AZADIRACHTA INDICA-A JUSS (NEEM)
title_sort some pharmacological actions of ‘nimbidin’- a bitter principle of azadirachta indica-a juss (neem)
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331505/
https://www.ncbi.nlm.nih.gov/pubmed/22557456
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