Cargando…

Peripheral Blood Monocyte Gene Expression Profile Clinically Stratifies Patients With Recent-Onset Type 1 Diabetes

Novel biomarkers of disease progression after type 1 diabetes onset are needed. We profiled peripheral blood (PB) monocyte gene expression in six healthy subjects and 16 children with type 1 diabetes diagnosed ∼3 months previously and analyzed clinical features from diagnosis to 1 year. Monocyte exp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Irvine, Katharine M., Gallego, Patricia, An, Xiaoyu, Best, Shannon E., Thomas, Gethin, Wells, Christine, Harris, Mark, Cotterill, Andrew, Thomas, Ranjeny
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2012
Materias:	Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331753/ https://www.ncbi.nlm.nih.gov/pubmed/22403299 http://dx.doi.org/10.2337/db11-1549

Ejemplares similares

Risk of Type 1 Diabetes Progression in Islet Autoantibody-Positive Children Can Be Further Stratified Using Expression Patterns of Multiple Genes Implicated in Peripheral Blood Lymphocyte Activation and Function
por: Jin, Yulan, et al.
Publicado: (2014)

Monocyte miRNAs Are Associated With Type 2 Diabetes
por: Parker, Daniel C., et al.
Publicado: (2022)

Epigenetic Changes in Islets of Langerhans Preceding the Onset of Diabetes
por: Ouni, Meriem, et al.
Publicado: (2020)

Presence of PD-1 similarity genes in monocytes may promote the development of type 1 diabetes mellitus and poor prognosis of pancreatic cancer
por: Huang, Yuquan, et al.
Publicado: (2023)

Peripheral Blood Transcriptomic Signatures of Fasting Glucose and Insulin Concentrations
por: Chen, Brian H., et al.
Publicado: (2016)

Glutathione S-transferases gene polymorphism influence on the age of diabetes type 2 onset
por: Klusek, Justyna, et al.
Publicado: (2020)

Immunoproteomic Profiling of Antiviral Antibodies in New-Onset Type 1 Diabetes Using Protein Arrays
por: Bian, Xiaofang, et al.
Publicado: (2016)

Loss of MANF Causes Childhood-Onset Syndromic Diabetes Due to Increased Endoplasmic Reticulum Stress
por: Montaser, Hossam, et al.
Publicado: (2021)

Molecular and clinical characteristics of monogenic diabetes mellitus in southern Chinese children with onset before 3 years of age
por: Lin, Yunting, et al.
Publicado: (2020)

Identification of candidate gene variants of monogenic diabetes using targeted panel sequencing in early onset diabetes patients
por: Lee, Dong-Hwa, et al.
Publicado: (2021)

GATA6 Mutations Cause a Broad Phenotypic Spectrum of Diabetes From Pancreatic Agenesis to Adult-Onset Diabetes Without Exocrine Insufficiency
por: De Franco, Elisa, et al.
Publicado: (2013)

New clinical screening strategy to distinguish HNF1A variant-induced diabetes from young early-onset type 2 diabetes in a Chinese population
por: Ma, Yumin, et al.
Publicado: (2020)

Short Leukocyte Telomere Length Predicts Risk of Diabetes in American Indians: the Strong Heart Family Study
por: Zhao, Jinying, et al.
Publicado: (2014)

A Gene-Family Analysis of 61 Genetic Variants in the Nicotinic Acetylcholine Receptor Genes for Insulin Resistance and Type 2 Diabetes in American Indians
por: Yang, Jingyun, et al.
Publicado: (2012)

Two novel type 2 diabetes loci revealed through integration of TCF7L2 DNA occupancy and SNP association data
por: Johnson, Matthew E, et al.
Publicado: (2014)

Metabolite Profiles of Diabetes Incidence and Intervention Response in the Diabetes Prevention Program
por: Walford, Geoffrey A., et al.
Publicado: (2016)

Dimethylglycine Deficiency and the Development of Diabetes
por: Magnusson, Martin, et al.
Publicado: (2015)

Identification of Cross-Species Shared Transcriptional Networks of Diabetic Nephropathy in Human and Mouse Glomeruli
por: Hodgin, Jeffrey B., et al.
Publicado: (2013)

Evaluation of Evidence for Pathogenicity Demonstrates That BLK, KLF11, and PAX4 Should Not Be Included in Diagnostic Testing for MODY
por: Laver, Thomas W., et al.
Publicado: (2022)

Sulfated Progesterone Metabolites That Enhance Insulin Secretion via TRPM3 Are Reduced in Serum From Women With Gestational Diabetes Mellitus
por: Fan, Hei Man, et al.
Publicado: (2022)

A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response
por: Pappalardo, Zachary, et al.
Publicado: (2017)

Identification of Serum Metabolites Associated With Risk of Type 2 Diabetes Using a Targeted Metabolomic Approach
por: Floegel, Anna, et al.
Publicado: (2013)

Improved Performance of Dynamic Measures of Insulin Response Over Surrogate Indices to Identify Genetic Contributors of Type 2 Diabetes: The GUARDIAN Consortium
por: Palmer, Nicholette D., et al.
Publicado: (2016)

Metabolomic Changes in Serum of Children with Different Clinical Diagnoses of Malnutrition(1)(2)(3)
por: Di Giovanni, Valeria, et al.
Publicado: (2016)

Metabolic Footprinting of Fermented Milk Consumption in Serum of Healthy Men
por: Pimentel, Grégory, et al.
Publicado: (2018)

The Plasma Proteome Is Associated with Anthropometric Status of Undernourished Nepalese School-Aged Children(1)(2)(3)
por: Lee, Sun Eun, et al.
Publicado: (2017)

Identification of Milk and Cheese Intake Biomarkers in Healthy Adults Reveals High Interindividual Variability of Lewis System–Related Oligosaccharides
por: Pimentel, Grégory, et al.
Publicado: (2020)

Treatment with Nitrate, but Not Nitrite, Lowers the Oxygen Cost of Exercise and Decreases Glycolytic Intermediates While Increasing Fatty Acid Metabolites in Exercised Zebrafish
por: Axton, Elizabeth R, et al.
Publicado: (2019)

Personalized Profiling Reveals Donor- and Lactation-Specific Trends in the Human Milk Proteome and Peptidome
por: Zhu, Jing, et al.
Publicado: (2021)

Urine Metabolite Profiles and Nutrient Intake Based on 4-Day Weighed Food Diary in Habitual Vegans, Vegetarians, and Omnivores
por: Lindqvist, Helen M, et al.
Publicado: (2020)

DHA Supplementation Attenuates Inflammation-Associated Gene Expression in the Mammary Gland of Lactating Mothers Who Deliver Preterm
por: Adams, Joselyn M, et al.
Publicado: (2022)

Plasma MicroRNA Signature of Alcohol Consumption: The Rotterdam Study
por: Karabegović, Irma, et al.
Publicado: (2022)

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
por: Scott, Robert A., et al.
Publicado: (2017)

Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes
por: Teumer, Alexander, et al.
Publicado: (2016)

Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium
por: Palmer, Nicholette D., et al.
Publicado: (2015)

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants
por: Wood, Andrew R., et al.
Publicado: (2017)

Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity
por: Dimas, Antigone S., et al.
Publicado: (2014)

Deep Resequencing Unveils Genetic Architecture of ADIPOQ and Identifies a Novel Low-Frequency Variant Strongly Associated With Adiponectin Variation
por: Warren, Liling L., et al.
Publicado: (2012)

No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels
por: Scott, Robert A., et al.
Publicado: (2012)

Placental Adiponectin Gene DNA Methylation Levels Are Associated With Mothers’ Blood Glucose Concentration
por: Bouchard, Luigi, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_adoop7i127osj09ofp2duggod6