Loss of HGF/c-Met Signaling in Pancreatic β-Cells Leads to Incomplete Maternal β-Cell Adaptation and Gestational Diabetes Mellitus

Hepatocyte growth factor (HGF) is a mitogen and insulinotropic agent for the β-cell. However, whether HGF/c-Met has a role in maternal β-cell adaptation during pregnancy is unknown. To address this issue, we characterized glucose and β-cell homeostasis in pregnant mice lacking c-Met in the pancreas...

Descripción completa

Detalles Bibliográficos
Autores principales: Demirci, Cem, Ernst, Sara, Alvarez-Perez, Juan C., Rosa, Taylor, Valle, Shelley, Shridhar, Varsha, Casinelli, Gabriella P., Alonso, Laura C., Vasavada, Rupangi C., García-Ocana, Adolfo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331762/
https://www.ncbi.nlm.nih.gov/pubmed/22427375
http://dx.doi.org/10.2337/db11-1154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331762/
https://www.ncbi.nlm.nih.gov/pubmed/22427375
http://dx.doi.org/10.2337/db11-1154

Ejemplares similares