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Loss of HGF/c-Met Signaling in Pancreatic β-Cells Leads to Incomplete Maternal β-Cell Adaptation and Gestational Diabetes Mellitus

Hepatocyte growth factor (HGF) is a mitogen and insulinotropic agent for the β-cell. However, whether HGF/c-Met has a role in maternal β-cell adaptation during pregnancy is unknown. To address this issue, we characterized glucose and β-cell homeostasis in pregnant mice lacking c-Met in the pancreas...

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Detalles Bibliográficos
Autores principales:	Demirci, Cem, Ernst, Sara, Alvarez-Perez, Juan C., Rosa, Taylor, Valle, Shelley, Shridhar, Varsha, Casinelli, Gabriella P., Alonso, Laura C., Vasavada, Rupangi C., García-Ocana, Adolfo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2012
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331762/ https://www.ncbi.nlm.nih.gov/pubmed/22427375 http://dx.doi.org/10.2337/db11-1154

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