Large-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons

BACKGROUND: A central goal in Huntington's disease (HD) research is to identify and prioritize candidate targets for neuroprotective intervention, which requires genome-scale information on the modifiers of early-stage neuron injury in HD. RESULTS: Here, we performed a large-scale RNA interfere...

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Detalles Bibliográficos
Autores principales: Lejeune, François-Xavier, Mesrob, Lilia, Parmentier, Frédéric, Bicep, Cedric, Vazquez-Manrique, Rafael P, Parker, J Alex, Vert, Jean-Philippe, Tourette, Cendrine, Neri, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331833/
https://www.ncbi.nlm.nih.gov/pubmed/22413862
http://dx.doi.org/10.1186/1471-2164-13-91

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