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Disruption of a GATA4/Ankrd1 Signaling Axis in Cardiomyocytes Leads to Sarcomere Disarray: Implications for Anthracycline Cardiomyopathy

Doxorubicin (Adriamycin) is an effective anti-cancer drug, but its clinical usage is limited by a dose-dependent cardiotoxicity characterized by widespread sarcomere disarray and loss of myofilaments. Cardiac ankyrin repeat protein (CARP, ANKRD1) is a transcriptional regulatory protein that is extre...

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Detalles Bibliográficos
Autores principales:	Chen, Billy, Zhong, Lin, Roush, Sarah F., Pentassuglia, Laura, Peng, Xuyang, Samaras, Susan, Davidson, Jeffrey M., Sawyer, Douglas B., Lim, Chee Chew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332030/ https://www.ncbi.nlm.nih.gov/pubmed/22532871 http://dx.doi.org/10.1371/journal.pone.0035743

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