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Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease
The brain changes in response to experience and altered environment. To do that, the nervous system often remodels the structures of neuronal circuits. This structural plasticity of the neuronal circuits appears to be controlled not only by intrinsic factors, but also by extrinsic mechanisms includi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332068/ https://www.ncbi.nlm.nih.gov/pubmed/22567285 http://dx.doi.org/10.1155/2012/789083 |
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author | Fujioka, Hiromi Dairyo, Yusuke Yasunaga, Kei-ichiro Emoto, Kazuo |
author_facet | Fujioka, Hiromi Dairyo, Yusuke Yasunaga, Kei-ichiro Emoto, Kazuo |
author_sort | Fujioka, Hiromi |
collection | PubMed |
description | The brain changes in response to experience and altered environment. To do that, the nervous system often remodels the structures of neuronal circuits. This structural plasticity of the neuronal circuits appears to be controlled not only by intrinsic factors, but also by extrinsic mechanisms including modification of the extracellular matrix. Recent studies employing a range of animal models implicate that matrix metalloproteinases regulate multiple aspects of the neuronal development and remodeling in the brain. This paper aims to summarize recent advances of our knowledge on the neuronal functions of matrix metalloproteinases and discuss how they might relate in neuronal disease. |
format | Online Article Text |
id | pubmed-3332068 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33320682012-05-07 Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease Fujioka, Hiromi Dairyo, Yusuke Yasunaga, Kei-ichiro Emoto, Kazuo Biochem Res Int Review Article The brain changes in response to experience and altered environment. To do that, the nervous system often remodels the structures of neuronal circuits. This structural plasticity of the neuronal circuits appears to be controlled not only by intrinsic factors, but also by extrinsic mechanisms including modification of the extracellular matrix. Recent studies employing a range of animal models implicate that matrix metalloproteinases regulate multiple aspects of the neuronal development and remodeling in the brain. This paper aims to summarize recent advances of our knowledge on the neuronal functions of matrix metalloproteinases and discuss how they might relate in neuronal disease. Hindawi Publishing Corporation 2012 2012-04-10 /pmc/articles/PMC3332068/ /pubmed/22567285 http://dx.doi.org/10.1155/2012/789083 Text en Copyright © 2012 Hiromi Fujioka et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Fujioka, Hiromi Dairyo, Yusuke Yasunaga, Kei-ichiro Emoto, Kazuo Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease |
title | Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease |
title_full | Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease |
title_fullStr | Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease |
title_full_unstemmed | Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease |
title_short | Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease |
title_sort | neural functions of matrix metalloproteinases: plasticity, neurogenesis, and disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332068/ https://www.ncbi.nlm.nih.gov/pubmed/22567285 http://dx.doi.org/10.1155/2012/789083 |
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