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Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease

The brain changes in response to experience and altered environment. To do that, the nervous system often remodels the structures of neuronal circuits. This structural plasticity of the neuronal circuits appears to be controlled not only by intrinsic factors, but also by extrinsic mechanisms includi...

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Autores principales: Fujioka, Hiromi, Dairyo, Yusuke, Yasunaga, Kei-ichiro, Emoto, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332068/
https://www.ncbi.nlm.nih.gov/pubmed/22567285
http://dx.doi.org/10.1155/2012/789083
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author Fujioka, Hiromi
Dairyo, Yusuke
Yasunaga, Kei-ichiro
Emoto, Kazuo
author_facet Fujioka, Hiromi
Dairyo, Yusuke
Yasunaga, Kei-ichiro
Emoto, Kazuo
author_sort Fujioka, Hiromi
collection PubMed
description The brain changes in response to experience and altered environment. To do that, the nervous system often remodels the structures of neuronal circuits. This structural plasticity of the neuronal circuits appears to be controlled not only by intrinsic factors, but also by extrinsic mechanisms including modification of the extracellular matrix. Recent studies employing a range of animal models implicate that matrix metalloproteinases regulate multiple aspects of the neuronal development and remodeling in the brain. This paper aims to summarize recent advances of our knowledge on the neuronal functions of matrix metalloproteinases and discuss how they might relate in neuronal disease.
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spelling pubmed-33320682012-05-07 Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease Fujioka, Hiromi Dairyo, Yusuke Yasunaga, Kei-ichiro Emoto, Kazuo Biochem Res Int Review Article The brain changes in response to experience and altered environment. To do that, the nervous system often remodels the structures of neuronal circuits. This structural plasticity of the neuronal circuits appears to be controlled not only by intrinsic factors, but also by extrinsic mechanisms including modification of the extracellular matrix. Recent studies employing a range of animal models implicate that matrix metalloproteinases regulate multiple aspects of the neuronal development and remodeling in the brain. This paper aims to summarize recent advances of our knowledge on the neuronal functions of matrix metalloproteinases and discuss how they might relate in neuronal disease. Hindawi Publishing Corporation 2012 2012-04-10 /pmc/articles/PMC3332068/ /pubmed/22567285 http://dx.doi.org/10.1155/2012/789083 Text en Copyright © 2012 Hiromi Fujioka et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Fujioka, Hiromi
Dairyo, Yusuke
Yasunaga, Kei-ichiro
Emoto, Kazuo
Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease
title Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease
title_full Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease
title_fullStr Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease
title_full_unstemmed Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease
title_short Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease
title_sort neural functions of matrix metalloproteinases: plasticity, neurogenesis, and disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332068/
https://www.ncbi.nlm.nih.gov/pubmed/22567285
http://dx.doi.org/10.1155/2012/789083
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