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Antidepressant-Like Activity of the Ethanolic Extract from Uncaria lanosa Wallich var. appendiculata Ridsd in the Forced Swimming Test and in the Tail Suspension Test in Mice

This study investigated the antidepressant activity of ethanolic extract of U. lanosa Wallich var. appendiculata Ridsd (UL(EtOH)) for two-weeks administrations by using FST and TST on mice. In order to understand the probable mechanism of antidepressant-like activity of UL(EtOH) in FST and TST, the...

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Autores principales: Hsu, Lieh-Ching, Ko, Yu-Jen, Cheng, Hao-Yuan, Chang, Ching-Wen, Lin, Yu-Chin, Cheng, Ying-Hui, Hsieh, Ming-Tsuen, Peng, Wen Huang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332070/
https://www.ncbi.nlm.nih.gov/pubmed/22567032
http://dx.doi.org/10.1155/2012/497302
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author Hsu, Lieh-Ching
Ko, Yu-Jen
Cheng, Hao-Yuan
Chang, Ching-Wen
Lin, Yu-Chin
Cheng, Ying-Hui
Hsieh, Ming-Tsuen
Peng, Wen Huang
author_facet Hsu, Lieh-Ching
Ko, Yu-Jen
Cheng, Hao-Yuan
Chang, Ching-Wen
Lin, Yu-Chin
Cheng, Ying-Hui
Hsieh, Ming-Tsuen
Peng, Wen Huang
author_sort Hsu, Lieh-Ching
collection PubMed
description This study investigated the antidepressant activity of ethanolic extract of U. lanosa Wallich var. appendiculata Ridsd (UL(EtOH)) for two-weeks administrations by using FST and TST on mice. In order to understand the probable mechanism of antidepressant-like activity of UL(EtOH) in FST and TST, the researchers measured the levels of monoamines and monoamine oxidase activities in mice brain, and combined the antidepressant drugs (fluoxetine, imipramine, maprotiline, clorgyline, bupropion and ketanserin). Lastly, the researchers analyzed the content of RHY in the UL(EtOH). The results showed that UL(EtOH) exhibited antidepressant-like activity in FST and TST in mice. UL(EtOH) increased the levels of 5-HT and 5-HIAA in cortex, striatum, hippocampus, and hypothalamus, the levels of NE and MHPG in cortex and hippocampus, the level of NE in striatum, and the level of DOPAC in striatum. Two-week injection of IMI, CLO, FLU and KET enhanced the antidepressant-like activity of UL(EtOH). UL(EtOH) inhibited the activity of MAO-A. The amount of RHY in UL(EtOH) was 17.12 mg/g extract. Our findings support the view that UL(EtOH) exerts antidepressant-like activity. The antidepressant-like mechanism of UL(EtOH) may be related to the increase in monoamines levels in the hippocampus, cortex, striatum, and hypothalamus of mice.
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spelling pubmed-33320702012-05-07 Antidepressant-Like Activity of the Ethanolic Extract from Uncaria lanosa Wallich var. appendiculata Ridsd in the Forced Swimming Test and in the Tail Suspension Test in Mice Hsu, Lieh-Ching Ko, Yu-Jen Cheng, Hao-Yuan Chang, Ching-Wen Lin, Yu-Chin Cheng, Ying-Hui Hsieh, Ming-Tsuen Peng, Wen Huang Evid Based Complement Alternat Med Research Article This study investigated the antidepressant activity of ethanolic extract of U. lanosa Wallich var. appendiculata Ridsd (UL(EtOH)) for two-weeks administrations by using FST and TST on mice. In order to understand the probable mechanism of antidepressant-like activity of UL(EtOH) in FST and TST, the researchers measured the levels of monoamines and monoamine oxidase activities in mice brain, and combined the antidepressant drugs (fluoxetine, imipramine, maprotiline, clorgyline, bupropion and ketanserin). Lastly, the researchers analyzed the content of RHY in the UL(EtOH). The results showed that UL(EtOH) exhibited antidepressant-like activity in FST and TST in mice. UL(EtOH) increased the levels of 5-HT and 5-HIAA in cortex, striatum, hippocampus, and hypothalamus, the levels of NE and MHPG in cortex and hippocampus, the level of NE in striatum, and the level of DOPAC in striatum. Two-week injection of IMI, CLO, FLU and KET enhanced the antidepressant-like activity of UL(EtOH). UL(EtOH) inhibited the activity of MAO-A. The amount of RHY in UL(EtOH) was 17.12 mg/g extract. Our findings support the view that UL(EtOH) exerts antidepressant-like activity. The antidepressant-like mechanism of UL(EtOH) may be related to the increase in monoamines levels in the hippocampus, cortex, striatum, and hypothalamus of mice. Hindawi Publishing Corporation 2012 2012-04-09 /pmc/articles/PMC3332070/ /pubmed/22567032 http://dx.doi.org/10.1155/2012/497302 Text en Copyright © 2012 Lieh-Ching Hsu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hsu, Lieh-Ching
Ko, Yu-Jen
Cheng, Hao-Yuan
Chang, Ching-Wen
Lin, Yu-Chin
Cheng, Ying-Hui
Hsieh, Ming-Tsuen
Peng, Wen Huang
Antidepressant-Like Activity of the Ethanolic Extract from Uncaria lanosa Wallich var. appendiculata Ridsd in the Forced Swimming Test and in the Tail Suspension Test in Mice
title Antidepressant-Like Activity of the Ethanolic Extract from Uncaria lanosa Wallich var. appendiculata Ridsd in the Forced Swimming Test and in the Tail Suspension Test in Mice
title_full Antidepressant-Like Activity of the Ethanolic Extract from Uncaria lanosa Wallich var. appendiculata Ridsd in the Forced Swimming Test and in the Tail Suspension Test in Mice
title_fullStr Antidepressant-Like Activity of the Ethanolic Extract from Uncaria lanosa Wallich var. appendiculata Ridsd in the Forced Swimming Test and in the Tail Suspension Test in Mice
title_full_unstemmed Antidepressant-Like Activity of the Ethanolic Extract from Uncaria lanosa Wallich var. appendiculata Ridsd in the Forced Swimming Test and in the Tail Suspension Test in Mice
title_short Antidepressant-Like Activity of the Ethanolic Extract from Uncaria lanosa Wallich var. appendiculata Ridsd in the Forced Swimming Test and in the Tail Suspension Test in Mice
title_sort antidepressant-like activity of the ethanolic extract from uncaria lanosa wallich var. appendiculata ridsd in the forced swimming test and in the tail suspension test in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332070/
https://www.ncbi.nlm.nih.gov/pubmed/22567032
http://dx.doi.org/10.1155/2012/497302
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