Parkinson's Disease DJ-1 L166P Alters rRNA Biogenesis by Exclusion of TTRAP from the Nucleolus and Sequestration into Cytoplasmic Aggregates via TRAF6

Mutations in PARK7/DJ-1 gene are associated to autosomal recessive early onset forms of Parkinson's disease (PD). Although large gene deletions have been linked to a loss-of-function phenotype, the pathogenic mechanism of missense mutations is less clear. The L166P mutation causes misfolding of...

Descripción completa

Detalles Bibliográficos
Autores principales: Vilotti, Sandra, Codrich, Marta, Dal Ferro, Marco, Pinto, Milena, Ferrer, Isidro, Collavin, Licio, Gustincich, Stefano, Zucchelli, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332112/
https://www.ncbi.nlm.nih.gov/pubmed/22532838
http://dx.doi.org/10.1371/journal.pone.0035051

Ejemplares similares

Ejemplares similares