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Insulin Facilitates the Recovery of Myocardial Contractility and Conduction during Cardiac Compression in Rabbits with Bupivacaine-Induced Cardiovascular Collapse

Bupivacaine inhibits cardiac conduction and contractility. Insulin enhances cardiac repolarization and myocardial contractility. We hypothesizes that insulin therapy would be effective in resuscitating bupivacaine-induced cardiac toxicity in rabbits. Twelve rabbits were tracheally intubated and midl...

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Autores principales: Yang, Solmon, Uugangerel, Tserendorj, Jang, In-ki, Lee, Hyung-chul, Kim, Jong Min, Kang, Byeong-Cheol, Kim, Chong Soo, Lee, Kook-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332159/
https://www.ncbi.nlm.nih.gov/pubmed/22567005
http://dx.doi.org/10.1155/2012/878764
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author Yang, Solmon
Uugangerel, Tserendorj
Jang, In-ki
Lee, Hyung-chul
Kim, Jong Min
Kang, Byeong-Cheol
Kim, Chong Soo
Lee, Kook-Hyun
author_facet Yang, Solmon
Uugangerel, Tserendorj
Jang, In-ki
Lee, Hyung-chul
Kim, Jong Min
Kang, Byeong-Cheol
Kim, Chong Soo
Lee, Kook-Hyun
author_sort Yang, Solmon
collection PubMed
description Bupivacaine inhibits cardiac conduction and contractility. Insulin enhances cardiac repolarization and myocardial contractility. We hypothesizes that insulin therapy would be effective in resuscitating bupivacaine-induced cardiac toxicity in rabbits. Twelve rabbits were tracheally intubated and midline sternotomy was performed under general anesthesia. Cardiovascular collapse (CVC) was induced by an IV bolus injection of bupivacaine 10 mg/kg. The rabbits were treated with either saline (control) or insulin injection, administered as a 2 U/kg bolus. Internal cardiac massage was performed until the return of spontaneous circulation (ROSC) and the time to the return of sinus rhythm (ROSR) was also noted in both groups. Arterial blood pressure, and electrocardiography were continuously monitored for 30 min and plasma bupivacaine concentrations at every 5 min. The ROSC, ROSR and normalization of QRS duration were attained faster in the insulin-treated group than in the control group. At the ROSC, there was a significant difference in bupivacaine concentration between two groups. Insulin facilitates the return of myocardial contractility and conduction from bupivacaine-induced CVC in rabbits. However, recovery of cardiac conduction is dependent mainly on the change of plasma bupivacaine concentrations.
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spelling pubmed-33321592012-05-07 Insulin Facilitates the Recovery of Myocardial Contractility and Conduction during Cardiac Compression in Rabbits with Bupivacaine-Induced Cardiovascular Collapse Yang, Solmon Uugangerel, Tserendorj Jang, In-ki Lee, Hyung-chul Kim, Jong Min Kang, Byeong-Cheol Kim, Chong Soo Lee, Kook-Hyun Anesthesiol Res Pract Research Article Bupivacaine inhibits cardiac conduction and contractility. Insulin enhances cardiac repolarization and myocardial contractility. We hypothesizes that insulin therapy would be effective in resuscitating bupivacaine-induced cardiac toxicity in rabbits. Twelve rabbits were tracheally intubated and midline sternotomy was performed under general anesthesia. Cardiovascular collapse (CVC) was induced by an IV bolus injection of bupivacaine 10 mg/kg. The rabbits were treated with either saline (control) or insulin injection, administered as a 2 U/kg bolus. Internal cardiac massage was performed until the return of spontaneous circulation (ROSC) and the time to the return of sinus rhythm (ROSR) was also noted in both groups. Arterial blood pressure, and electrocardiography were continuously monitored for 30 min and plasma bupivacaine concentrations at every 5 min. The ROSC, ROSR and normalization of QRS duration were attained faster in the insulin-treated group than in the control group. At the ROSC, there was a significant difference in bupivacaine concentration between two groups. Insulin facilitates the return of myocardial contractility and conduction from bupivacaine-induced CVC in rabbits. However, recovery of cardiac conduction is dependent mainly on the change of plasma bupivacaine concentrations. Hindawi Publishing Corporation 2012 2012-04-11 /pmc/articles/PMC3332159/ /pubmed/22567005 http://dx.doi.org/10.1155/2012/878764 Text en Copyright © 2012 Solmon Yang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yang, Solmon
Uugangerel, Tserendorj
Jang, In-ki
Lee, Hyung-chul
Kim, Jong Min
Kang, Byeong-Cheol
Kim, Chong Soo
Lee, Kook-Hyun
Insulin Facilitates the Recovery of Myocardial Contractility and Conduction during Cardiac Compression in Rabbits with Bupivacaine-Induced Cardiovascular Collapse
title Insulin Facilitates the Recovery of Myocardial Contractility and Conduction during Cardiac Compression in Rabbits with Bupivacaine-Induced Cardiovascular Collapse
title_full Insulin Facilitates the Recovery of Myocardial Contractility and Conduction during Cardiac Compression in Rabbits with Bupivacaine-Induced Cardiovascular Collapse
title_fullStr Insulin Facilitates the Recovery of Myocardial Contractility and Conduction during Cardiac Compression in Rabbits with Bupivacaine-Induced Cardiovascular Collapse
title_full_unstemmed Insulin Facilitates the Recovery of Myocardial Contractility and Conduction during Cardiac Compression in Rabbits with Bupivacaine-Induced Cardiovascular Collapse
title_short Insulin Facilitates the Recovery of Myocardial Contractility and Conduction during Cardiac Compression in Rabbits with Bupivacaine-Induced Cardiovascular Collapse
title_sort insulin facilitates the recovery of myocardial contractility and conduction during cardiac compression in rabbits with bupivacaine-induced cardiovascular collapse
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332159/
https://www.ncbi.nlm.nih.gov/pubmed/22567005
http://dx.doi.org/10.1155/2012/878764
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