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Critical appraisal of ceftaroline in the management of community-acquired bacterial pneumonia and skin infections

Ceftaroline is a novel broad-spectrum cephalosporin β-lactam antibiotic with activity against methicillin-resistant Staphylococcus aureus (MRSA) as well as multidrug-resistant Streptococcus pneumoniae among other routine Gram positive and Gram negative organisms. It has been approved by the US Food...

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Detalles Bibliográficos
Autores principales: Goodman, Julian J, Martin, Stanley I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333463/
https://www.ncbi.nlm.nih.gov/pubmed/22547933
http://dx.doi.org/10.2147/TCRM.S17413
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author Goodman, Julian J
Martin, Stanley I
author_facet Goodman, Julian J
Martin, Stanley I
author_sort Goodman, Julian J
collection PubMed
description Ceftaroline is a novel broad-spectrum cephalosporin β-lactam antibiotic with activity against methicillin-resistant Staphylococcus aureus (MRSA) as well as multidrug-resistant Streptococcus pneumoniae among other routine Gram positive and Gram negative organisms. It has been approved by the US Food and Drug Administration for treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections (ABSSSIs). Ceftaroline is approved for treatment of ABSSSI due to MRSA, however currently there are no data for pneumonia due to MRSA in humans. Herein we review the major clinical trials as well as ceftaroline microbiology, pharmacokinetics, and safety, followed by a look at further directions for investigation of this new agent.
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spelling pubmed-33334632012-04-30 Critical appraisal of ceftaroline in the management of community-acquired bacterial pneumonia and skin infections Goodman, Julian J Martin, Stanley I Ther Clin Risk Manag Review Ceftaroline is a novel broad-spectrum cephalosporin β-lactam antibiotic with activity against methicillin-resistant Staphylococcus aureus (MRSA) as well as multidrug-resistant Streptococcus pneumoniae among other routine Gram positive and Gram negative organisms. It has been approved by the US Food and Drug Administration for treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections (ABSSSIs). Ceftaroline is approved for treatment of ABSSSI due to MRSA, however currently there are no data for pneumonia due to MRSA in humans. Herein we review the major clinical trials as well as ceftaroline microbiology, pharmacokinetics, and safety, followed by a look at further directions for investigation of this new agent. Dove Medical Press 2012 2012-03-26 /pmc/articles/PMC3333463/ /pubmed/22547933 http://dx.doi.org/10.2147/TCRM.S17413 Text en © 2012 Goodman and Martin, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Goodman, Julian J
Martin, Stanley I
Critical appraisal of ceftaroline in the management of community-acquired bacterial pneumonia and skin infections
title Critical appraisal of ceftaroline in the management of community-acquired bacterial pneumonia and skin infections
title_full Critical appraisal of ceftaroline in the management of community-acquired bacterial pneumonia and skin infections
title_fullStr Critical appraisal of ceftaroline in the management of community-acquired bacterial pneumonia and skin infections
title_full_unstemmed Critical appraisal of ceftaroline in the management of community-acquired bacterial pneumonia and skin infections
title_short Critical appraisal of ceftaroline in the management of community-acquired bacterial pneumonia and skin infections
title_sort critical appraisal of ceftaroline in the management of community-acquired bacterial pneumonia and skin infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333463/
https://www.ncbi.nlm.nih.gov/pubmed/22547933
http://dx.doi.org/10.2147/TCRM.S17413
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