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Regulation of TGF-β receptor activity
TGF-β signaling regulates diverse cellular processes, including cell proliferation, differentiation, apoptosis, cell plasticity and migration. Its dysfunctions can result in various kinds of diseases, such as cancer and tissue fibrosis. TGF-β signaling is tightly regulated at different levels along...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333473/ https://www.ncbi.nlm.nih.gov/pubmed/22420375 http://dx.doi.org/10.1186/2045-3701-2-9 |
| _version_ | 1782230457408028672 |
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| author | Huang, Fei Chen, Ye-Guang |
| author_facet | Huang, Fei Chen, Ye-Guang |
| author_sort | Huang, Fei |
| collection | PubMed |
| description | TGF-β signaling regulates diverse cellular processes, including cell proliferation, differentiation, apoptosis, cell plasticity and migration. Its dysfunctions can result in various kinds of diseases, such as cancer and tissue fibrosis. TGF-β signaling is tightly regulated at different levels along the pathway, and modulation of TGF-β receptor activity is a critical step for signaling regulation. This review focuses on our recent understanding of regulation of TGF-β receptor activity. |
| format | Online Article Text |
| id | pubmed-3333473 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-33334732012-04-24 Regulation of TGF-β receptor activity Huang, Fei Chen, Ye-Guang Cell Biosci Review TGF-β signaling regulates diverse cellular processes, including cell proliferation, differentiation, apoptosis, cell plasticity and migration. Its dysfunctions can result in various kinds of diseases, such as cancer and tissue fibrosis. TGF-β signaling is tightly regulated at different levels along the pathway, and modulation of TGF-β receptor activity is a critical step for signaling regulation. This review focuses on our recent understanding of regulation of TGF-β receptor activity. BioMed Central 2012-03-15 /pmc/articles/PMC3333473/ /pubmed/22420375 http://dx.doi.org/10.1186/2045-3701-2-9 Text en Copyright ©2012 Huang and Chen; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Review Huang, Fei Chen, Ye-Guang Regulation of TGF-β receptor activity |
| title | Regulation of TGF-β receptor activity |
| title_full | Regulation of TGF-β receptor activity |
| title_fullStr | Regulation of TGF-β receptor activity |
| title_full_unstemmed | Regulation of TGF-β receptor activity |
| title_short | Regulation of TGF-β receptor activity |
| title_sort | regulation of tgf-β receptor activity |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333473/ https://www.ncbi.nlm.nih.gov/pubmed/22420375 http://dx.doi.org/10.1186/2045-3701-2-9 |
| work_keys_str_mv | AT huangfei regulationoftgfbreceptoractivity AT chenyeguang regulationoftgfbreceptoractivity |