Cargando…
A case of thrombotic thrombocytopenic purpura induced by acute pancreatitis
Thrombotic thrombocytopenic purpura (TTP) is a multisystemic microvascular disorder that may be caused by an imbalance between unusually large von Willebrand factor multimers and the cleaving protease ADAMTS13. In acquired TTP, especially in secondary TTP with various underlying diseases, the diagno...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333833/ https://www.ncbi.nlm.nih.gov/pubmed/22536085 http://dx.doi.org/10.2147/IJGM.S30271 |
_version_ | 1782230530964586496 |
---|---|
author | Arimoto, Miyoko Komiyama, Yutaka Okamae, Fumiko Ichibe, Akemi Teranishi, Setsuko Tokunaga, Hirohiko Nakaya, Keiko Fujiwara, Michie Yamaoka, Manabu Onishi, Shuji Miyamoto, Rie Nakamichi, Naoto Nomura, Shosaku |
author_facet | Arimoto, Miyoko Komiyama, Yutaka Okamae, Fumiko Ichibe, Akemi Teranishi, Setsuko Tokunaga, Hirohiko Nakaya, Keiko Fujiwara, Michie Yamaoka, Manabu Onishi, Shuji Miyamoto, Rie Nakamichi, Naoto Nomura, Shosaku |
author_sort | Arimoto, Miyoko |
collection | PubMed |
description | Thrombotic thrombocytopenic purpura (TTP) is a multisystemic microvascular disorder that may be caused by an imbalance between unusually large von Willebrand factor multimers and the cleaving protease ADAMTS13. In acquired TTP, especially in secondary TTP with various underlying diseases, the diagnosis is difficult because there are many cases that do not exhibit severe deficiency of ADAMTS13 or raised levels of ADAMST13 inhibitors. It is well known that collagen disease, malignancy, and hematopoietic stem cell transplantation can be underlying conditions that induce TTP. However, TTP induced by acute pancreatitis, as experienced by our patient, has rarely been reported. Our patient completely recovered with treatments using steroids and plasma exchange (PE) only. In cases where patients develop acute pancreatitis with no apparent causes for hemolytic anemia and thrombocytopenia, the possibility of TTP should be considered. Treatments for TTP including PE should be evaluated as soon as a diagnosis is made. |
format | Online Article Text |
id | pubmed-3333833 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-33338332012-04-25 A case of thrombotic thrombocytopenic purpura induced by acute pancreatitis Arimoto, Miyoko Komiyama, Yutaka Okamae, Fumiko Ichibe, Akemi Teranishi, Setsuko Tokunaga, Hirohiko Nakaya, Keiko Fujiwara, Michie Yamaoka, Manabu Onishi, Shuji Miyamoto, Rie Nakamichi, Naoto Nomura, Shosaku Int J Gen Med Case Report Thrombotic thrombocytopenic purpura (TTP) is a multisystemic microvascular disorder that may be caused by an imbalance between unusually large von Willebrand factor multimers and the cleaving protease ADAMTS13. In acquired TTP, especially in secondary TTP with various underlying diseases, the diagnosis is difficult because there are many cases that do not exhibit severe deficiency of ADAMTS13 or raised levels of ADAMST13 inhibitors. It is well known that collagen disease, malignancy, and hematopoietic stem cell transplantation can be underlying conditions that induce TTP. However, TTP induced by acute pancreatitis, as experienced by our patient, has rarely been reported. Our patient completely recovered with treatments using steroids and plasma exchange (PE) only. In cases where patients develop acute pancreatitis with no apparent causes for hemolytic anemia and thrombocytopenia, the possibility of TTP should be considered. Treatments for TTP including PE should be evaluated as soon as a diagnosis is made. Dove Medical Press 2012-03-28 /pmc/articles/PMC3333833/ /pubmed/22536085 http://dx.doi.org/10.2147/IJGM.S30271 Text en © 2012 Arimoto et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Case Report Arimoto, Miyoko Komiyama, Yutaka Okamae, Fumiko Ichibe, Akemi Teranishi, Setsuko Tokunaga, Hirohiko Nakaya, Keiko Fujiwara, Michie Yamaoka, Manabu Onishi, Shuji Miyamoto, Rie Nakamichi, Naoto Nomura, Shosaku A case of thrombotic thrombocytopenic purpura induced by acute pancreatitis |
title | A case of thrombotic thrombocytopenic purpura induced by acute pancreatitis |
title_full | A case of thrombotic thrombocytopenic purpura induced by acute pancreatitis |
title_fullStr | A case of thrombotic thrombocytopenic purpura induced by acute pancreatitis |
title_full_unstemmed | A case of thrombotic thrombocytopenic purpura induced by acute pancreatitis |
title_short | A case of thrombotic thrombocytopenic purpura induced by acute pancreatitis |
title_sort | case of thrombotic thrombocytopenic purpura induced by acute pancreatitis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333833/ https://www.ncbi.nlm.nih.gov/pubmed/22536085 http://dx.doi.org/10.2147/IJGM.S30271 |
work_keys_str_mv | AT arimotomiyoko acaseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis AT komiyamayutaka acaseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis AT okamaefumiko acaseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis AT ichibeakemi acaseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis AT teranishisetsuko acaseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis AT tokunagahirohiko acaseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis AT nakayakeiko acaseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis AT fujiwaramichie acaseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis AT yamaokamanabu acaseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis AT onishishuji acaseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis AT miyamotorie acaseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis AT nakamichinaoto acaseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis AT nomurashosaku acaseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis AT arimotomiyoko caseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis AT komiyamayutaka caseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis AT okamaefumiko caseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis AT ichibeakemi caseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis AT teranishisetsuko caseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis AT tokunagahirohiko caseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis AT nakayakeiko caseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis AT fujiwaramichie caseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis AT yamaokamanabu caseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis AT onishishuji caseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis AT miyamotorie caseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis AT nakamichinaoto caseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis AT nomurashosaku caseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis |