Cargando…

A case of thrombotic thrombocytopenic purpura induced by acute pancreatitis

Thrombotic thrombocytopenic purpura (TTP) is a multisystemic microvascular disorder that may be caused by an imbalance between unusually large von Willebrand factor multimers and the cleaving protease ADAMTS13. In acquired TTP, especially in secondary TTP with various underlying diseases, the diagno...

Descripción completa

Detalles Bibliográficos
Autores principales: Arimoto, Miyoko, Komiyama, Yutaka, Okamae, Fumiko, Ichibe, Akemi, Teranishi, Setsuko, Tokunaga, Hirohiko, Nakaya, Keiko, Fujiwara, Michie, Yamaoka, Manabu, Onishi, Shuji, Miyamoto, Rie, Nakamichi, Naoto, Nomura, Shosaku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333833/
https://www.ncbi.nlm.nih.gov/pubmed/22536085
http://dx.doi.org/10.2147/IJGM.S30271
_version_ 1782230530964586496
author Arimoto, Miyoko
Komiyama, Yutaka
Okamae, Fumiko
Ichibe, Akemi
Teranishi, Setsuko
Tokunaga, Hirohiko
Nakaya, Keiko
Fujiwara, Michie
Yamaoka, Manabu
Onishi, Shuji
Miyamoto, Rie
Nakamichi, Naoto
Nomura, Shosaku
author_facet Arimoto, Miyoko
Komiyama, Yutaka
Okamae, Fumiko
Ichibe, Akemi
Teranishi, Setsuko
Tokunaga, Hirohiko
Nakaya, Keiko
Fujiwara, Michie
Yamaoka, Manabu
Onishi, Shuji
Miyamoto, Rie
Nakamichi, Naoto
Nomura, Shosaku
author_sort Arimoto, Miyoko
collection PubMed
description Thrombotic thrombocytopenic purpura (TTP) is a multisystemic microvascular disorder that may be caused by an imbalance between unusually large von Willebrand factor multimers and the cleaving protease ADAMTS13. In acquired TTP, especially in secondary TTP with various underlying diseases, the diagnosis is difficult because there are many cases that do not exhibit severe deficiency of ADAMTS13 or raised levels of ADAMST13 inhibitors. It is well known that collagen disease, malignancy, and hematopoietic stem cell transplantation can be underlying conditions that induce TTP. However, TTP induced by acute pancreatitis, as experienced by our patient, has rarely been reported. Our patient completely recovered with treatments using steroids and plasma exchange (PE) only. In cases where patients develop acute pancreatitis with no apparent causes for hemolytic anemia and thrombocytopenia, the possibility of TTP should be considered. Treatments for TTP including PE should be evaluated as soon as a diagnosis is made.
format Online
Article
Text
id pubmed-3333833
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-33338332012-04-25 A case of thrombotic thrombocytopenic purpura induced by acute pancreatitis Arimoto, Miyoko Komiyama, Yutaka Okamae, Fumiko Ichibe, Akemi Teranishi, Setsuko Tokunaga, Hirohiko Nakaya, Keiko Fujiwara, Michie Yamaoka, Manabu Onishi, Shuji Miyamoto, Rie Nakamichi, Naoto Nomura, Shosaku Int J Gen Med Case Report Thrombotic thrombocytopenic purpura (TTP) is a multisystemic microvascular disorder that may be caused by an imbalance between unusually large von Willebrand factor multimers and the cleaving protease ADAMTS13. In acquired TTP, especially in secondary TTP with various underlying diseases, the diagnosis is difficult because there are many cases that do not exhibit severe deficiency of ADAMTS13 or raised levels of ADAMST13 inhibitors. It is well known that collagen disease, malignancy, and hematopoietic stem cell transplantation can be underlying conditions that induce TTP. However, TTP induced by acute pancreatitis, as experienced by our patient, has rarely been reported. Our patient completely recovered with treatments using steroids and plasma exchange (PE) only. In cases where patients develop acute pancreatitis with no apparent causes for hemolytic anemia and thrombocytopenia, the possibility of TTP should be considered. Treatments for TTP including PE should be evaluated as soon as a diagnosis is made. Dove Medical Press 2012-03-28 /pmc/articles/PMC3333833/ /pubmed/22536085 http://dx.doi.org/10.2147/IJGM.S30271 Text en © 2012 Arimoto et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Case Report
Arimoto, Miyoko
Komiyama, Yutaka
Okamae, Fumiko
Ichibe, Akemi
Teranishi, Setsuko
Tokunaga, Hirohiko
Nakaya, Keiko
Fujiwara, Michie
Yamaoka, Manabu
Onishi, Shuji
Miyamoto, Rie
Nakamichi, Naoto
Nomura, Shosaku
A case of thrombotic thrombocytopenic purpura induced by acute pancreatitis
title A case of thrombotic thrombocytopenic purpura induced by acute pancreatitis
title_full A case of thrombotic thrombocytopenic purpura induced by acute pancreatitis
title_fullStr A case of thrombotic thrombocytopenic purpura induced by acute pancreatitis
title_full_unstemmed A case of thrombotic thrombocytopenic purpura induced by acute pancreatitis
title_short A case of thrombotic thrombocytopenic purpura induced by acute pancreatitis
title_sort case of thrombotic thrombocytopenic purpura induced by acute pancreatitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333833/
https://www.ncbi.nlm.nih.gov/pubmed/22536085
http://dx.doi.org/10.2147/IJGM.S30271
work_keys_str_mv AT arimotomiyoko acaseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis
AT komiyamayutaka acaseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis
AT okamaefumiko acaseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis
AT ichibeakemi acaseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis
AT teranishisetsuko acaseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis
AT tokunagahirohiko acaseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis
AT nakayakeiko acaseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis
AT fujiwaramichie acaseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis
AT yamaokamanabu acaseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis
AT onishishuji acaseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis
AT miyamotorie acaseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis
AT nakamichinaoto acaseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis
AT nomurashosaku acaseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis
AT arimotomiyoko caseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis
AT komiyamayutaka caseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis
AT okamaefumiko caseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis
AT ichibeakemi caseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis
AT teranishisetsuko caseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis
AT tokunagahirohiko caseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis
AT nakayakeiko caseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis
AT fujiwaramichie caseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis
AT yamaokamanabu caseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis
AT onishishuji caseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis
AT miyamotorie caseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis
AT nakamichinaoto caseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis
AT nomurashosaku caseofthromboticthrombocytopenicpurpurainducedbyacutepancreatitis