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Secondary binding sites for heavily modified triplex forming oligonucleotides

In order to enhance DNA triple helix stability synthetic oligonucleotides have been developed that bear amino groups on the sugar or base. One of the most effective of these is bis-amino-U (B), which possesses 5-propargylamino and 2′-aminoethoxy modifications. Inclusion of this modified nucleotide n...

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Detalles Bibliográficos
Autores principales:	Cardew, Antonia S., Brown, Tom, Fox, Keith R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Synthetic Biology and Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333850/ https://www.ncbi.nlm.nih.gov/pubmed/22180535 http://dx.doi.org/10.1093/nar/gkr1119

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