Cargando…

Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity

The TET family of FE(II) and 2-oxoglutarate-dependent enzymes (Tet1/2/3) promote DNA demethylation by converting 5-methylcytosine to 5-hydroxymethylcytosine (5hmC), which they further oxidize into 5-formylcytosine and 5-carboxylcytosine. Tet1 is robustly expressed in mouse embryonic stem cells (mESC...

Descripción completa

Detalles Bibliográficos
Autores principales:	Freudenberg, Johannes M., Ghosh, Swati, Lackford, Brad L., Yellaboina, Sailu, Zheng, Xiaofeng, Li, Ruifang, Cuddapah, Suresh, Wade, Paul A., Hu, Guang, Jothi, Raja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Gene Regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333871/ https://www.ncbi.nlm.nih.gov/pubmed/22210859 http://dx.doi.org/10.1093/nar/gkr1253

Ejemplares similares

Structure of Naegleria Tet-like dioxygenase (NgTet1) in complexes with a reaction intermediate 5-hydroxymethylcytosine DNA
por: Hashimoto, Hideharu, et al.
Publicado: (2015)

Genomic mapping of 5-hydroxymethylcytosine in the human brain
por: Jin, Seung-Gi, et al.
Publicado: (2011)

Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells
por: Menendez, Daniel, et al.
Publicado: (2013)

Single base resolution analysis of 5-hydroxymethylcytosine in 188 human genes: implications for hepatic gene expression
por: Ivanov, Maxim, et al.
Publicado: (2016)

Functional impacts of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine at a single hemi-modified CpG dinucleotide in a gene promoter
por: Kitsera, Nataliya, et al.
Publicado: (2017)

TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation
por: Müller, Udo, et al.
Publicado: (2014)

TET1 is a maintenance DNA demethylase that prevents methylation spreading in differentiated cells
por: Jin, Chunlei, et al.
Publicado: (2014)

Quantitative assessment of Tet-induced oxidation products of 5-methylcytosine in cellular and tissue DNA
por: Liu, Shuo, et al.
Publicado: (2013)

A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer
por: Good, Charly R., et al.
Publicado: (2017)

APOBEC3A efficiently deaminates methylated, but not TET-oxidized, cytosine bases in DNA
por: Schutsky, Emily K., et al.
Publicado: (2017)

TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation
por: Stolz, Paul, et al.
Publicado: (2022)

A TetR-like regulator broadly affects the expressions of diverse genes in Mycobacterium smegmatis
por: Yang, Min, et al.
Publicado: (2012)

Binding of MBD proteins to DNA blocks Tet1 function thereby modulating transcriptional noise
por: Ludwig, Anne K., et al.
Publicado: (2017)

The HDAC7–TET2 epigenetic axis is essential during early B lymphocyte development
por: Azagra, Alba, et al.
Publicado: (2022)

TET1 is controlled by pluripotency-associated factors in ESCs and downmodulated by PRC2 in differentiated cells and tissues
por: Neri, Francesco, et al.
Publicado: (2015)

FOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function
por: Yang, Yeqing A., et al.
Publicado: (2016)

A primary role of TET proteins in establishment and maintenance of De Novo bivalency at CpG islands
por: Kong, Lingchun, et al.
Publicado: (2016)

Phosphorylation of Tet3 by cdk5 is critical for robust activation of BRN2 during neuronal differentiation
por: Rao, Vinay Kumar, et al.
Publicado: (2020)

Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism
por: Zhao, Bailin, et al.
Publicado: (2014)

Tet1 facilitates hypoxia tolerance by stabilizing the HIF-α proteins independent of its methylcytosine dioxygenase activity
por: Wang, Jing, et al.
Publicado: (2017)

Sin3a–Tet1 interaction activates gene transcription and is required for embryonic stem cell pluripotency
por: Zhu, Fugui, et al.
Publicado: (2018)

Nono deficiency compromises TET1 chromatin association and impedes neuronal differentiation of mouse embryonic stem cells
por: Li, Wenjing, et al.
Publicado: (2020)

TET2- and TDG-mediated changes are required for the acquisition of distinct histone modifications in divergent terminal differentiation of myeloid cells
por: Garcia-Gomez, Antonio, et al.
Publicado: (2017)

Crucial role of iron in epigenetic rewriting during adipocyte differentiation mediated by JMJD1A and TET2 activity
por: Suzuki, Tomohiro, et al.
Publicado: (2023)

Dual functions of TET1 in germ layer lineage bifurcation distinguished by genomic context and dependence on 5-methylcytosine oxidation
por: van der Veer, Bernard K, et al.
Publicado: (2023)

MicroRNA-29b/Tet1 regulatory axis epigenetically modulates mesendoderm differentiation in mouse embryonic stem cells
por: Tu, Jiajie, et al.
Publicado: (2015)

Oxygen gradients can determine epigenetic asymmetry and cellular differentiation via differential regulation of Tet activity in embryonic stem cells
por: Burr, Simon, et al.
Publicado: (2018)

An HDAC2-TET1 switch at distinct chromatin regions significantly promotes the maturation of pre-iPS to iPS cells
por: Wei, Tingyi, et al.
Publicado: (2015)

Methyl-CpG binding domain protein 1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner
por: Zhang, Peng, et al.
Publicado: (2017)

The DNA dioxygenase Tet1 regulates H3K27 modification and embryonic stem cell biology independent of its catalytic activity
por: Chrysanthou, Stephanie, et al.
Publicado: (2022)

Selective association between nucleosomes with identical DNA sequences
por: Nishikawa, Jun-ichi, et al.
Publicado: (2013)

TET1 modulates H4K16 acetylation by controlling auto-acetylation of hMOF to affect gene regulation and DNA repair function
por: Zhong, Jianing, et al.
Publicado: (2017)

Acute depletion of CTCF directly affects MYC regulation through loss of enhancer–promoter looping
por: Hyle, Judith, et al.
Publicado: (2019)

Transcriptional network dynamics during the progression of pluripotency revealed by integrative statistical learning
por: Kim, Hani Jieun, et al.
Publicado: (2020)

Low RNA stability signifies increased post-transcriptional regulation of cell identity genes
por: Li, Yanqiang, et al.
Publicado: (2023)

Histone H1 depletion triggers an interferon response in cancer cells via activation of heterochromatic repeats
por: Izquierdo-Bouldstridge, Andrea, et al.
Publicado: (2017)

The nucleosome position-encoding WW/SS sequence pattern is depleted in mammalian genes relative to other eukaryotes
por: Wright, Gregory M, et al.
Publicado: (2019)

DOT1L promotes progenitor proliferation and primes neuronal layer identity in the developing cerebral cortex
por: Franz, Henriette, et al.
Publicado: (2019)

Gcn5 facilitates Pol II progression, rather than recruitment to nucleosome-depleted stress promoters, in Schizosaccharomyces pombe
por: Sansó, Miriam, et al.
Publicado: (2011)

Coordinated changes in gene expression, H1 variant distribution and genome 3D conformation in response to H1 depletion
por: Serna-Pujol, Núria, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_6c1r9i5o10ulsld3h3r2ch4k51