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Gene targeting to the ROSA26 locus directed by engineered zinc finger nucleases

Targeted gene addition to mammalian genomes is central to biotechnology, basic research and gene therapy. For example, gene targeting to the ROSA26 locus by homologous recombination in embryonic stem cells is commonly used for mouse transgenesis to achieve ubiquitous and persistent transgene express...

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Detalles Bibliográficos
Autores principales:	Perez-Pinera, Pablo, Ousterout, David G., Brown, Matthew T., Gersbach, Charles A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Synthetic Biology and Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333879/ https://www.ncbi.nlm.nih.gov/pubmed/22169954 http://dx.doi.org/10.1093/nar/gkr1214

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