Genetically modified mouse models of cancer invasion and metastasis

Tumor invasion and metastasis is a multi-step process that requires adaptation of cancer cells to conditions that they encounter during their journey to distant body sites. Understanding the molecular processes that underlie this adaptation is of exceeding importance because most cancer patients die...

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Autores principales: Rampetsreiter, Paulina, Casanova, Emilio, Eferl, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2011
Materias:
Cell Migration and Metastasis Formation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334252/
https://www.ncbi.nlm.nih.gov/pubmed/22577462
http://dx.doi.org/10.1016/j.ddmod.2011.05.003
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author Rampetsreiter, Paulina
Casanova, Emilio
Eferl, Robert
author_facet Rampetsreiter, Paulina
Casanova, Emilio
Eferl, Robert
author_sort Rampetsreiter, Paulina
collection PubMed
description Tumor invasion and metastasis is a multi-step process that requires adaptation of cancer cells to conditions that they encounter during their journey to distant body sites. Understanding the molecular processes that underlie this adaptation is of exceeding importance because most cancer patients die because of metastases rather than primary tumors. In this review we assess genetically engineered mouse models (GEMMs) that have been established to investigate mechanisms of cancer invasion and metastasis.
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spelling pubmed-33342522012-05-08 Genetically modified mouse models of cancer invasion and metastasis Rampetsreiter, Paulina Casanova, Emilio Eferl, Robert Drug Discov Today Dis Models Cell Migration and Metastasis Formation Tumor invasion and metastasis is a multi-step process that requires adaptation of cancer cells to conditions that they encounter during their journey to distant body sites. Understanding the molecular processes that underlie this adaptation is of exceeding importance because most cancer patients die because of metastases rather than primary tumors. In this review we assess genetically engineered mouse models (GEMMs) that have been established to investigate mechanisms of cancer invasion and metastasis. Elsevier 2011 2011-07-01 /pmc/articles/PMC3334252/ /pubmed/22577462 http://dx.doi.org/10.1016/j.ddmod.2011.05.003 Text en © 2011 Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/3.0/ Open Access under CC BY-NC-ND 3.0 (https://creativecommons.org/licenses/by-nc-nd/3.0/) license
spellingShingle Cell Migration and Metastasis Formation
Rampetsreiter, Paulina
Casanova, Emilio
Eferl, Robert
Genetically modified mouse models of cancer invasion and metastasis
title Genetically modified mouse models of cancer invasion and metastasis
title_full Genetically modified mouse models of cancer invasion and metastasis
title_fullStr Genetically modified mouse models of cancer invasion and metastasis
title_full_unstemmed Genetically modified mouse models of cancer invasion and metastasis
title_short Genetically modified mouse models of cancer invasion and metastasis
title_sort genetically modified mouse models of cancer invasion and metastasis
topic Cell Migration and Metastasis Formation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334252/
https://www.ncbi.nlm.nih.gov/pubmed/22577462
http://dx.doi.org/10.1016/j.ddmod.2011.05.003
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