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Phosphorylation events during viral infections provide potential therapeutic targets

For many medically relevant viruses, there is now considerable evidence that both viral and cellular kinases play important roles in viral infection. Ultimately, these kinases, and the cellular signaling pathways that they exploit, may serve as therapeutic targets for treating patients. Currently, s...

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Detalles Bibliográficos
Autores principales: Keating, Julie A., Striker, Rob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334462/
https://www.ncbi.nlm.nih.gov/pubmed/22113983
http://dx.doi.org/10.1002/rmv.722
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author Keating, Julie A.
Striker, Rob
author_facet Keating, Julie A.
Striker, Rob
author_sort Keating, Julie A.
collection PubMed
description For many medically relevant viruses, there is now considerable evidence that both viral and cellular kinases play important roles in viral infection. Ultimately, these kinases, and the cellular signaling pathways that they exploit, may serve as therapeutic targets for treating patients. Currently, small molecule inhibitors of kinases are under investigation as therapy for herpes viral infections. Additionally, a number of cellular or host‐directed tyrosine kinase inhibitors that have been previously FDA approved for cancer treatment are under study in animal models and clinical trials, as they have shown promise for the treatment of various viral infections as well. This review will highlight the wide range of viral proteins phosphorylated by viral and cellular kinases, and the potential for variability of kinase recognition sites within viral substrates to impact phosphorylation and kinase prediction. Research studying kinase‐targeting prophylactic and therapeutic treatments for a number of viral infections will also be discussed. Copyright © 2011 John Wiley & Sons, Ltd.
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spelling pubmed-33344622013-05-01 Phosphorylation events during viral infections provide potential therapeutic targets Keating, Julie A. Striker, Rob Rev Med Virol Reviews For many medically relevant viruses, there is now considerable evidence that both viral and cellular kinases play important roles in viral infection. Ultimately, these kinases, and the cellular signaling pathways that they exploit, may serve as therapeutic targets for treating patients. Currently, small molecule inhibitors of kinases are under investigation as therapy for herpes viral infections. Additionally, a number of cellular or host‐directed tyrosine kinase inhibitors that have been previously FDA approved for cancer treatment are under study in animal models and clinical trials, as they have shown promise for the treatment of various viral infections as well. This review will highlight the wide range of viral proteins phosphorylated by viral and cellular kinases, and the potential for variability of kinase recognition sites within viral substrates to impact phosphorylation and kinase prediction. Research studying kinase‐targeting prophylactic and therapeutic treatments for a number of viral infections will also be discussed. Copyright © 2011 John Wiley & Sons, Ltd. John Wiley & Sons, Ltd 2012-05 2011-11-24 /pmc/articles/PMC3334462/ /pubmed/22113983 http://dx.doi.org/10.1002/rmv.722 Text en Copyright © 2011 John Wiley & Sons, Ltd. This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.
spellingShingle Reviews
Keating, Julie A.
Striker, Rob
Phosphorylation events during viral infections provide potential therapeutic targets
title Phosphorylation events during viral infections provide potential therapeutic targets
title_full Phosphorylation events during viral infections provide potential therapeutic targets
title_fullStr Phosphorylation events during viral infections provide potential therapeutic targets
title_full_unstemmed Phosphorylation events during viral infections provide potential therapeutic targets
title_short Phosphorylation events during viral infections provide potential therapeutic targets
title_sort phosphorylation events during viral infections provide potential therapeutic targets
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334462/
https://www.ncbi.nlm.nih.gov/pubmed/22113983
http://dx.doi.org/10.1002/rmv.722
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