Cargando…
Phosphorylation events during viral infections provide potential therapeutic targets
For many medically relevant viruses, there is now considerable evidence that both viral and cellular kinases play important roles in viral infection. Ultimately, these kinases, and the cellular signaling pathways that they exploit, may serve as therapeutic targets for treating patients. Currently, s...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334462/ https://www.ncbi.nlm.nih.gov/pubmed/22113983 http://dx.doi.org/10.1002/rmv.722 |
_version_ | 1782230628914167808 |
---|---|
author | Keating, Julie A. Striker, Rob |
author_facet | Keating, Julie A. Striker, Rob |
author_sort | Keating, Julie A. |
collection | PubMed |
description | For many medically relevant viruses, there is now considerable evidence that both viral and cellular kinases play important roles in viral infection. Ultimately, these kinases, and the cellular signaling pathways that they exploit, may serve as therapeutic targets for treating patients. Currently, small molecule inhibitors of kinases are under investigation as therapy for herpes viral infections. Additionally, a number of cellular or host‐directed tyrosine kinase inhibitors that have been previously FDA approved for cancer treatment are under study in animal models and clinical trials, as they have shown promise for the treatment of various viral infections as well. This review will highlight the wide range of viral proteins phosphorylated by viral and cellular kinases, and the potential for variability of kinase recognition sites within viral substrates to impact phosphorylation and kinase prediction. Research studying kinase‐targeting prophylactic and therapeutic treatments for a number of viral infections will also be discussed. Copyright © 2011 John Wiley & Sons, Ltd. |
format | Online Article Text |
id | pubmed-3334462 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-33344622013-05-01 Phosphorylation events during viral infections provide potential therapeutic targets Keating, Julie A. Striker, Rob Rev Med Virol Reviews For many medically relevant viruses, there is now considerable evidence that both viral and cellular kinases play important roles in viral infection. Ultimately, these kinases, and the cellular signaling pathways that they exploit, may serve as therapeutic targets for treating patients. Currently, small molecule inhibitors of kinases are under investigation as therapy for herpes viral infections. Additionally, a number of cellular or host‐directed tyrosine kinase inhibitors that have been previously FDA approved for cancer treatment are under study in animal models and clinical trials, as they have shown promise for the treatment of various viral infections as well. This review will highlight the wide range of viral proteins phosphorylated by viral and cellular kinases, and the potential for variability of kinase recognition sites within viral substrates to impact phosphorylation and kinase prediction. Research studying kinase‐targeting prophylactic and therapeutic treatments for a number of viral infections will also be discussed. Copyright © 2011 John Wiley & Sons, Ltd. John Wiley & Sons, Ltd 2012-05 2011-11-24 /pmc/articles/PMC3334462/ /pubmed/22113983 http://dx.doi.org/10.1002/rmv.722 Text en Copyright © 2011 John Wiley & Sons, Ltd. This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency. |
spellingShingle | Reviews Keating, Julie A. Striker, Rob Phosphorylation events during viral infections provide potential therapeutic targets |
title | Phosphorylation events during viral infections provide potential therapeutic targets |
title_full | Phosphorylation events during viral infections provide potential therapeutic targets |
title_fullStr | Phosphorylation events during viral infections provide potential therapeutic targets |
title_full_unstemmed | Phosphorylation events during viral infections provide potential therapeutic targets |
title_short | Phosphorylation events during viral infections provide potential therapeutic targets |
title_sort | phosphorylation events during viral infections provide potential therapeutic targets |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334462/ https://www.ncbi.nlm.nih.gov/pubmed/22113983 http://dx.doi.org/10.1002/rmv.722 |
work_keys_str_mv | AT keatingjuliea phosphorylationeventsduringviralinfectionsprovidepotentialtherapeutictargets AT strikerrob phosphorylationeventsduringviralinfectionsprovidepotentialtherapeutictargets |